Metabolic factors affecting residual beta cell function assessed by C-peptide secretion in patients with newly diagnosed type 1 diabetes

A. Picardi, N. Visalli, A. Lauria, C. Suraci, R. Buzzetti, M. K. Merola, S. Manfrini, C. Guglielmi, U. V. Gentilucci, D. Pitocco, A. Crinò, C. Bizzarri, M. Cappa, Paolo Pozzilli

Research output: Contribution to journalArticle

Abstract

Background: In recent onset of type 1 diabetes, the residual beta cell function, assessed by baseline and/or stimulated C-peptide secretion, can be a useful parameter to establish the extension of beta cell destruction. How metabolic parameters at diagnosis influence residual C-peptide secretion is not well established. Patients and Methods: We analyzed 553 consecutive patients with recent onset (<4 weeks) of type 1 diabetes (250 females and 303 males, mean age 15 ± 8 years). Baseline and stimulated C-peptide by i.v. glucagon were evaluated using a highly sensitive radio-immunoassay. Metabolic parameters including blood glucose, HbA1c, insulin dose, and BMI were also evaluated. Results: Baseline and stimulated C-peptide were 0.26 ± 0.22 and 0.47 ± 0.38 nmol/1 and correlated positively with age (p <0.001). There was no significant correlation between C-peptide and blood glucose at diagnosis. BMI was positively correlated with both baseline and stimulated C-peptide secretion (p <0.001). By contrast, HbA1c levels inversely correlated with both baseline and stimulated C-peptide secretion (p<0.001). Conclusion: In type 1 diabetes at diagnosis, baseline and stimulated C-peptide are higher in pubertal and young adult patients compared with pre-pubertal patients suggesting that such parameter can be used as an end point marker for studies aimed at protecting and/or restoring beta cells in patients with substantial beta cell function. High levels of HbA1c and lower BMI are dependent variables of C-peptide values.

Original languageEnglish
Pages (from-to)668-672
Number of pages5
JournalHormone and Metabolic Research
Volume38
Issue number10
DOIs
Publication statusPublished - Oct 2006

Keywords

  • Baseline and stimulated C-peptide
  • HbA1c
  • Insulin dose
  • Type 1 diabetes

ASJC Scopus subject areas

  • Biochemistry
  • Endocrinology

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