Metabolic fate of caudate nucleus dopamine

Piero F. Spano, Norton H. Neff

Research output: Contribution to journalArticlepeer-review


The rate of formation of DM in the guinea pig caudate nucleus was estimated from the rate of conversion of radioactive tyrosine to DM and was found to be 32 nmole/g/h. The formation and elimination of HVA and Dopac from caudate was estimated from their accumulation after treatment with probenecid. Each acid was formed at a rate of about 15 nmole/g/h. A larger dose of probenecid was required to prevent the transport of Dopac from caudate than to prevent the transport of HVA.

Original languageEnglish
Pages (from-to)139-145
Number of pages7
JournalBrain Research
Issue number1
Publication statusPublished - Jul 13 1972

ASJC Scopus subject areas

  • Developmental Biology
  • Molecular Biology
  • Clinical Neurology
  • Neuroscience(all)


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