Precarietà metabolica nei pazienti con scompenso cardiaco cronico e malnutrizione

Translated title of the contribution: Metabolic frailty in malnourished heart failure patients

Alessandra Gualco, Cristina Opasich, Silvia Brazzo, Franco Cobelli, Evasio Pasini, Ornella Pastoris, Roberto Aquilani

Research output: Contribution to journalArticlepeer-review


Muscular wasting (MW) and cardiac cachexia (CC) are often present in patients with chronic heart failure (HF). Aim: To identify whether MW and CC are due to malnutrition or impairment of protein metabolism in HF patients. Material and Method: In 78 clinically stable HF patients (NYHA class II-III), aged from 32 to 89 years, we measured anthropometrical parameters and nutritional habits. In the identified 35 malnourished patients, we also measured: insulin resistance, gluconeogenetic amino acids blood concentration and nitrogen balance. Results: Seventy-five patients had eating-related symptoms. However we found significant nutritional impairment in 35 patients only. In addition, these 35 patients had: 1) significant increase of blood Alanine independently from both presence of insulin resistance or food intake reduction and 2) positive nitrogen balance. Conclusion: Food intake is not impaired in CHF patients. In spite of normal food intake, 35 of 78 patients had nutritional impairment with reduced anthropometric parameters and increased blood Alanine. These findings show alteration of proteins metabolism with proteolysis. We believe that specific physical training with nutritional supplement can be an additional therapy able to prevent protein disarrangement in CHF patients.

Translated title of the contributionMetabolic frailty in malnourished heart failure patients
Original languageItalian
Pages (from-to)115-120
Number of pages6
JournalMonaldi Archives for Chest Disease - Cardiac Series
Issue number2
Publication statusPublished - Jun 2007

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Pulmonary and Respiratory Medicine


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