Metabolic fuelling of proper T cell functions

Giuseppe Matarese, Alessandra Colamatteo, Veronica De Rosa

Research output: Contribution to journalArticle

Abstract

The interplay of the immune system with other aspects of physiology is one of the hottest topics of the recent literature. A crucial example is the influence of metabolic cues on immune responses. It is now well accepted that upon activation, T lymphocytes take on a metabolic profile profoundly distinct from that of their quiescent and anergic counterparts; in these sense, T cell metabolism is highly dynamic and has a serious impact on the ability of T cell to grow, activate and differentiate. Specific metabolic pathways provide energy and biosynthetic precursors able to support specific T cell functions, such as effector, regulatory and memory. Here, we review the main signaling pathways that control metabolism and how the metabolic phenotypes of T cell subtypes integrate with their specific function.

Original languageEnglish
Pages (from-to)174-178
Number of pages5
JournalImmunology Letters
Volume161
Issue number2
DOIs
Publication statusPublished - 2014

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Keywords

  • Adipose tissue
  • Metabolism
  • T cell
  • Tolerance
  • Treg cell

ASJC Scopus subject areas

  • Immunology
  • Immunology and Allergy
  • Medicine(all)

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