Metabolic fuelling of proper T cell functions

Giuseppe Matarese, Alessandra Colamatteo, Veronica De Rosa

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

The interplay of the immune system with other aspects of physiology is one of the hottest topics of the recent literature. A crucial example is the influence of metabolic cues on immune responses. It is now well accepted that upon activation, T lymphocytes take on a metabolic profile profoundly distinct from that of their quiescent and anergic counterparts; in these sense, T cell metabolism is highly dynamic and has a serious impact on the ability of T cell to grow, activate and differentiate. Specific metabolic pathways provide energy and biosynthetic precursors able to support specific T cell functions, such as effector, regulatory and memory. Here, we review the main signaling pathways that control metabolism and how the metabolic phenotypes of T cell subtypes integrate with their specific function.

Original languageEnglish
Pages (from-to)174-178
Number of pages5
JournalImmunology Letters
Volume161
Issue number2
DOIs
Publication statusPublished - 2014

Fingerprint

T-Lymphocytes
Aptitude
Metabolome
Metabolic Networks and Pathways
Cues
Immune System
Phenotype

Keywords

  • Adipose tissue
  • Metabolism
  • T cell
  • Tolerance
  • Treg cell

ASJC Scopus subject areas

  • Immunology
  • Immunology and Allergy
  • Medicine(all)

Cite this

Matarese, G., Colamatteo, A., & De Rosa, V. (2014). Metabolic fuelling of proper T cell functions. Immunology Letters, 161(2), 174-178. https://doi.org/10.1016/j.imlet.2013.12.012

Metabolic fuelling of proper T cell functions. / Matarese, Giuseppe; Colamatteo, Alessandra; De Rosa, Veronica.

In: Immunology Letters, Vol. 161, No. 2, 2014, p. 174-178.

Research output: Contribution to journalArticle

Matarese, G, Colamatteo, A & De Rosa, V 2014, 'Metabolic fuelling of proper T cell functions', Immunology Letters, vol. 161, no. 2, pp. 174-178. https://doi.org/10.1016/j.imlet.2013.12.012
Matarese, Giuseppe ; Colamatteo, Alessandra ; De Rosa, Veronica. / Metabolic fuelling of proper T cell functions. In: Immunology Letters. 2014 ; Vol. 161, No. 2. pp. 174-178.
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