Metabolic impairment in human amnesia: A PET study of memory networks

F. Fazio, D. Perani, M. C. Gilardi, F. Colombo, S. F. Cappa, G. Vallar, V. Bettinardi, E. Paulesu, M. Alberoni, S. Bressi, M. Franceschi, G. L. Lenzi

Research output: Contribution to journalArticle

Abstract

Human amnesia is a clinical syndrome exhibiting the failure to recall past events and to learn new information. Its 'pure' form, characterized by a selective impairment of long-term memory without any disorder of general intelligence or other cognitive functions, has been associated with lesions localized within Papez's circuit and some connected areas. Thus, amnesia could be due to a functional disconnection between components of this or other neural structures involved in long-term learning and retention. To test this hypothesis, we measured regional cerebral metabolism with 2- [ 18F]fluoro-2-deoxy-D-glucose ([ 18F]FDG) and positron emission tomography (PET) in 11 patients with 'pure' amnesia. A significant bilateral reduction in metabolism in a number of interconnected cerebral regions (hippocampal formation, thalamus, cingulate gyrus, and frontal basal cortex) was found in the amnesic patients in comparison with normal controls. The metabolic impairment did not correspond to alterations in structural anatomy as assessed by magnetic resonance imaging (MRI). These results are the first in vivo evidence for the role of a functional network as a basis of human memory.

Original languageEnglish
Pages (from-to)353-358
Number of pages6
JournalJournal of Cerebral Blood Flow and Metabolism
Volume12
Issue number3
Publication statusPublished - 1992

Fingerprint

Amnesia
Positron-Emission Tomography
Long-Term Memory
Gyrus Cinguli
Fluorodeoxyglucose F18
Frontal Lobe
Thalamus
Intelligence
Cognition
Hippocampus
Anatomy
Magnetic Resonance Imaging
Learning

Keywords

  • Memory
  • Neural network
  • Positron emission tomography

ASJC Scopus subject areas

  • Endocrinology
  • Endocrinology, Diabetes and Metabolism
  • Neuroscience(all)

Cite this

Fazio, F., Perani, D., Gilardi, M. C., Colombo, F., Cappa, S. F., Vallar, G., ... Lenzi, G. L. (1992). Metabolic impairment in human amnesia: A PET study of memory networks. Journal of Cerebral Blood Flow and Metabolism, 12(3), 353-358.

Metabolic impairment in human amnesia : A PET study of memory networks. / Fazio, F.; Perani, D.; Gilardi, M. C.; Colombo, F.; Cappa, S. F.; Vallar, G.; Bettinardi, V.; Paulesu, E.; Alberoni, M.; Bressi, S.; Franceschi, M.; Lenzi, G. L.

In: Journal of Cerebral Blood Flow and Metabolism, Vol. 12, No. 3, 1992, p. 353-358.

Research output: Contribution to journalArticle

Fazio, F, Perani, D, Gilardi, MC, Colombo, F, Cappa, SF, Vallar, G, Bettinardi, V, Paulesu, E, Alberoni, M, Bressi, S, Franceschi, M & Lenzi, GL 1992, 'Metabolic impairment in human amnesia: A PET study of memory networks', Journal of Cerebral Blood Flow and Metabolism, vol. 12, no. 3, pp. 353-358.
Fazio, F. ; Perani, D. ; Gilardi, M. C. ; Colombo, F. ; Cappa, S. F. ; Vallar, G. ; Bettinardi, V. ; Paulesu, E. ; Alberoni, M. ; Bressi, S. ; Franceschi, M. ; Lenzi, G. L. / Metabolic impairment in human amnesia : A PET study of memory networks. In: Journal of Cerebral Blood Flow and Metabolism. 1992 ; Vol. 12, No. 3. pp. 353-358.
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