Metabolic, inflammatory, endothelial and haemostatic markers in a group of Italian obese children and adolescents

Paola Giordano, Giovanni Carlo Del Vecchio, Valerio Cecinati, Maurizio Delvecchio, Maria Altomare, Fabrizia De Palma, Domenico De Mattia, Luciano Cavallo, Maria Felicia Faienza

Research output: Contribution to journalArticlepeer-review

Abstract

Childhood obesity and its related comorbidities are increasingly recognised in children, predisposing them to early cardiovascular disease and metabolic syndrome. The objective of the study was to investigate markers of metabolism, inflammation and haemostasis in a group of Italian obese children and adolescents. Fifty-nine obese and 40 non-obese subjects were recruited. Fasting glucose and insulin, total cholesterol, HDL and LDL cholesterol, triglycerides, high-sensitivity C-reactive protein (hsCRP), tumour necrosis factor alpha (TNF-α), and adiponectin were measured. Hypercoagulability was assessed by measuring the circulating levels of thrombin-antithrombin complex (TAT), D-dimer, fibrinogen, plasminogen activator inhibitor 1 (PAI-1) and von Willebrand Factor (vWF). A significant degree of insulin resistance was present in obese subjects compared with controls (p

Original languageEnglish
Pages (from-to)845-850
Number of pages6
JournalEuropean Journal of Pediatrics
Volume170
Issue number7
DOIs
Publication statusPublished - Jul 2011

Keywords

  • Childhood obesity
  • High-sensitivity C-reactive protein (hsCRP)
  • Plasminogen activator inhibitor 1 (PAI-1)
  • Thrombin-antithrombin complex (TAT)
  • Tumour necrosis factor alpha
  • von Willebrand Factor (vWF)

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health

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