Metabolic influence on the differentiation of suppressive myeloid cells in cancer

Chiara Porta, Arianna Marino, Francesca Maria Consonni, Augusto Bleve, Silvia Mola, Mariangela Storto, Elena Riboldi, Antonio Sica

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Abstract

New evidences indicate that the metabolic instruction of immunity (immune metabolism) results from the integration of cell metabolism and whole-body metabolism, which are both influenced by nutrition, microbiome metabolites and disease-driven metabolism (e.g. cancer metabolism). Cancer metabolism influences the immunological homeostasis and promotes immune alterations that support disease progression, hence influencing the clinical outcome. Cancer cells display increased glucose uptake and fermentation of glucose to lactate, even in the presence of completely functioning mitochondria. A major side effect of this event is immunosuppression, characterized by limited immunogenicity of cancer cells and restriction of the therapeutic efficacy of anticancer immunotherapy. Here, we discuss how the metabolism of myeloid cells associated with cancer contributes to the differentiation of their suppressive phenotype and therefore to cancer immune evasion.

Original languageEnglish
Pages (from-to)1095-1104
Number of pages10
JournalCarcinogenesis
Volume39
Issue number9
DOIs
Publication statusPublished - Sep 21 2018

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Porta, C., Marino, A., Consonni, F. M., Bleve, A., Mola, S., Storto, M., Riboldi, E., & Sica, A. (2018). Metabolic influence on the differentiation of suppressive myeloid cells in cancer. Carcinogenesis, 39(9), 1095-1104. https://doi.org/10.1093/carcin/bgy088