Metabolic influence on the differentiation of suppressive myeloid cells in cancer

Chiara Porta, Arianna Marino, Francesca Maria Consonni, Augusto Bleve, Silvia Mola, Mariangela Storto, Elena Riboldi, Antonio Sica

Research output: Contribution to journalArticle

Abstract

New evidences indicate that the metabolic instruction of immunity (immune metabolism) results from the integration of cell metabolism and whole-body metabolism, which are both influenced by nutrition, microbiome metabolites and disease-driven metabolism (e.g. cancer metabolism). Cancer metabolism influences the immunological homeostasis and promotes immune alterations that support disease progression, hence influencing the clinical outcome. Cancer cells display increased glucose uptake and fermentation of glucose to lactate, even in the presence of completely functioning mitochondria. A major side effect of this event is immunosuppression, characterized by limited immunogenicity of cancer cells and restriction of the therapeutic efficacy of anticancer immunotherapy. Here, we discuss how the metabolism of myeloid cells associated with cancer contributes to the differentiation of their suppressive phenotype and therefore to cancer immune evasion.

Original languageEnglish
Pages (from-to)1095-1104
Number of pages10
JournalCarcinogenesis
Volume39
Issue number9
DOIs
Publication statusPublished - Sep 21 2018

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Myeloid Cells
Neoplasms
Immune Evasion
Glucose
Microbiota
Immunotherapy
Immunosuppression
Fermentation
Disease Progression
Immunity
Lactic Acid
Mitochondria
Homeostasis
Phenotype

Cite this

Porta, C., Marino, A., Consonni, F. M., Bleve, A., Mola, S., Storto, M., ... Sica, A. (2018). Metabolic influence on the differentiation of suppressive myeloid cells in cancer. Carcinogenesis, 39(9), 1095-1104. https://doi.org/10.1093/carcin/bgy088

Metabolic influence on the differentiation of suppressive myeloid cells in cancer. / Porta, Chiara; Marino, Arianna; Consonni, Francesca Maria; Bleve, Augusto; Mola, Silvia; Storto, Mariangela; Riboldi, Elena; Sica, Antonio.

In: Carcinogenesis, Vol. 39, No. 9, 21.09.2018, p. 1095-1104.

Research output: Contribution to journalArticle

Porta, C, Marino, A, Consonni, FM, Bleve, A, Mola, S, Storto, M, Riboldi, E & Sica, A 2018, 'Metabolic influence on the differentiation of suppressive myeloid cells in cancer', Carcinogenesis, vol. 39, no. 9, pp. 1095-1104. https://doi.org/10.1093/carcin/bgy088
Porta C, Marino A, Consonni FM, Bleve A, Mola S, Storto M et al. Metabolic influence on the differentiation of suppressive myeloid cells in cancer. Carcinogenesis. 2018 Sep 21;39(9):1095-1104. https://doi.org/10.1093/carcin/bgy088
Porta, Chiara ; Marino, Arianna ; Consonni, Francesca Maria ; Bleve, Augusto ; Mola, Silvia ; Storto, Mariangela ; Riboldi, Elena ; Sica, Antonio. / Metabolic influence on the differentiation of suppressive myeloid cells in cancer. In: Carcinogenesis. 2018 ; Vol. 39, No. 9. pp. 1095-1104.
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