Abstract
In order to investigate the causes underlying metabolic instability in type I diabetes mellitus, we studied 8 unstable (group 1) and 4 well-controlled (group 2) diabetic patients, matched for age and duration of diabetes. Subjects were connected overnight to an artificial pancreas and brought to normoglycemia. On the following morning, insulin administration was discontinued for 6 hours and both metabolic and hormonal studies were carried out during this period. After insulin withdrawal, group 1 showed a faster rise of blood glucose (peak: 324.63±24.93 vs 175.25±42.63 mg/dl, p
Original language | English |
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Pages (from-to) | 215-221 |
Number of pages | 7 |
Journal | Acta Diabetologica Latina |
Volume | 22 |
Issue number | 3 |
DOIs | |
Publication status | Published - Jul 1985 |
Keywords
- Brittle diabetes
- C-peptide secretion
- Hepatic glucose production
- Metabolic instability
ASJC Scopus subject areas
- Internal Medicine
- Endocrinology, Diabetes and Metabolism
- Endocrinology