Metabolic instability in type I diabetic patients. Studies on insulin absorption, hepatic production of metabolites and glucose counterregulation

Piero Micossi; Marina Scavini; Flaviano Dosio; Lucilla Monti; Pier Marco Piatti

doi:10.1007/BF02590772

Metabolic instability in type I diabetic patients. Studies on insulin absorption, hepatic production of metabolites and glucose counterregulation

Piero Micossi, Marina Scavini, Flaviano Dosio, Lucilla Monti, Pier Marco Piatti

IRCCS Ospedale San Raffaele

Research output: Contribution to journal › Article › peer-review

Abstract

In order to investigate the causes underlying metabolic instability in type I diabetes mellitus, we studied 8 unstable (group 1) and 4 well-controlled (group 2) diabetic patients, matched for age and duration of diabetes. Subjects were connected overnight to an artificial pancreas and brought to normoglycemia. On the following morning, insulin administration was discontinued for 6 hours and both metabolic and hormonal studies were carried out during this period. After insulin withdrawal, group 1 showed a faster rise of blood glucose (peak: 324.63±24.93 vs 175.25±42.63 mg/dl, p

Original language	English
Pages (from-to)	215-221
Number of pages	7
Journal	Acta Diabetologica Latina
Volume	22
Issue number	3
DOIs	https://doi.org/10.1007/BF02590772
Publication status	Published - Jul 1985

Keywords

Brittle diabetes
C-peptide secretion
Hepatic glucose production
Metabolic instability

ASJC Scopus subject areas

Internal Medicine
Endocrinology, Diabetes and Metabolism
Endocrinology

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10.1007/BF02590772

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Metabolic instability in type I diabetic patients. Studies on insulin absorption, hepatic production of metabolites and glucose counterregulation. / Micossi, Piero; Scavini, Marina; Dosio, Flaviano; Monti, Lucilla ; Piatti, Pier Marco.

In: Acta Diabetologica Latina, Vol. 22, No. 3, 07.1985, p. 215-221.

Research output: Contribution to journal › Article › peer-review

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AU - Piatti, Pier Marco

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Metabolic instability in type I diabetic patients. Studies on insulin absorption, hepatic production of metabolites and glucose counterregulation

Abstract

Keywords

ASJC Scopus subject areas

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