Abstract
In order to investigate the causes underlying metabolic instability in type I diabetes mellitus, we studied 8 unstable (group 1) and 4 well-controlled (group 2) diabetic patients, matched for age and duration of diabetes. Subjects were connected overnight to an artificial pancreas and brought to normoglycemia. On the following morning, insulin administration was discontinued for 6 hours and both metabolic and hormonal studies were carried out during this period. After insulin withdrawal, group 1 showed a faster rise of blood glucose (peak: 324.63±24.93 vs 175.25±42.63 mg/dl, p
| Original language | English |
|---|---|
| Pages (from-to) | 215-221 |
| Number of pages | 7 |
| Journal | Acta Diabetologica Latina |
| Volume | 22 |
| Issue number | 3 |
| DOIs | |
| Publication status | Published - Jul 1985 |
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Keywords
- Brittle diabetes
- C-peptide secretion
- Hepatic glucose production
- Metabolic instability
ASJC Scopus subject areas
- Internal Medicine
- Endocrinology, Diabetes and Metabolism
- Endocrinology
Cite this
Metabolic instability in type I diabetic patients. Studies on insulin absorption, hepatic production of metabolites and glucose counterregulation. / Micossi, Piero; Scavini, Marina; Dosio, Flaviano; Monti, Lucilla; Piatti, Pier Marco.
In: Acta Diabetologica Latina, Vol. 22, No. 3, 07.1985, p. 215-221.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Metabolic instability in type I diabetic patients. Studies on insulin absorption, hepatic production of metabolites and glucose counterregulation
AU - Micossi, Piero
AU - Scavini, Marina
AU - Dosio, Flaviano
AU - Monti, Lucilla
AU - Piatti, Pier Marco
PY - 1985/7
Y1 - 1985/7
N2 - In order to investigate the causes underlying metabolic instability in type I diabetes mellitus, we studied 8 unstable (group 1) and 4 well-controlled (group 2) diabetic patients, matched for age and duration of diabetes. Subjects were connected overnight to an artificial pancreas and brought to normoglycemia. On the following morning, insulin administration was discontinued for 6 hours and both metabolic and hormonal studies were carried out during this period. After insulin withdrawal, group 1 showed a faster rise of blood glucose (peak: 324.63±24.93 vs 175.25±42.63 mg/dl, p
AB - In order to investigate the causes underlying metabolic instability in type I diabetes mellitus, we studied 8 unstable (group 1) and 4 well-controlled (group 2) diabetic patients, matched for age and duration of diabetes. Subjects were connected overnight to an artificial pancreas and brought to normoglycemia. On the following morning, insulin administration was discontinued for 6 hours and both metabolic and hormonal studies were carried out during this period. After insulin withdrawal, group 1 showed a faster rise of blood glucose (peak: 324.63±24.93 vs 175.25±42.63 mg/dl, p
KW - Brittle diabetes
KW - C-peptide secretion
KW - Hepatic glucose production
KW - Metabolic instability
UR - http://www.scopus.com/inward/record.url?scp=0022361143&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0022361143&partnerID=8YFLogxK
U2 - 10.1007/BF02590772
DO - 10.1007/BF02590772
M3 - Article
C2 - 3907236
AN - SCOPUS:0022361143
VL - 22
SP - 215
EP - 221
JO - Acta Diabetologica
JF - Acta Diabetologica
SN - 0940-5429
IS - 3
ER -