Metabolic instability in type I diabetic patients. Studies on insulin absorption, hepatic production of metabolites and glucose counterregulation

Piero Micossi, Marina Scavini, Flaviano Dosio, Lucilla Monti, Pier Marco Piatti

Research output: Contribution to journalArticle


In order to investigate the causes underlying metabolic instability in type I diabetes mellitus, we studied 8 unstable (group 1) and 4 well-controlled (group 2) diabetic patients, matched for age and duration of diabetes. Subjects were connected overnight to an artificial pancreas and brought to normoglycemia. On the following morning, insulin administration was discontinued for 6 hours and both metabolic and hormonal studies were carried out during this period. After insulin withdrawal, group 1 showed a faster rise of blood glucose (peak: 324.63±24.93 vs 175.25±42.63 mg/dl, p

Original languageEnglish
Pages (from-to)215-221
Number of pages7
JournalActa Diabetologica Latina
Issue number3
Publication statusPublished - Jul 1985



  • Brittle diabetes
  • C-peptide secretion
  • Hepatic glucose production
  • Metabolic instability

ASJC Scopus subject areas

  • Internal Medicine
  • Endocrinology, Diabetes and Metabolism
  • Endocrinology

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