Metabolic instability in type I diabetic patients. Studies on insulin absorption, hepatic production of metabolites and glucose counterregulation

Piero Micossi; Marina Scavini; Flaviano Dosio; Lucilla Monti; Pier Marco Piatti

doi:10.1007/BF02590772

Metabolic instability in type I diabetic patients. Studies on insulin absorption, hepatic production of metabolites and glucose counterregulation

Piero Micossi, Marina Scavini, Flaviano Dosio, Lucilla Monti, Pier Marco Piatti

IRCCS Ospedale San Raffaele

Research output: Contribution to journal › Article

Abstract

In order to investigate the causes underlying metabolic instability in type I diabetes mellitus, we studied 8 unstable (group 1) and 4 well-controlled (group 2) diabetic patients, matched for age and duration of diabetes. Subjects were connected overnight to an artificial pancreas and brought to normoglycemia. On the following morning, insulin administration was discontinued for 6 hours and both metabolic and hormonal studies were carried out during this period. After insulin withdrawal, group 1 showed a faster rise of blood glucose (peak: 324.63±24.93 vs 175.25±42.63 mg/dl, p

Original language	English
Pages (from-to)	215-221
Number of pages	7
Journal	Acta Diabetologica Latina
Volume	22
Issue number	3
DOIs	https://doi.org/10.1007/BF02590772
Publication status	Published - Jul 1985

Fingerprint

Keywords

Brittle diabetes
C-peptide secretion
Hepatic glucose production
Metabolic instability

ASJC Scopus subject areas

Internal Medicine
Endocrinology, Diabetes and Metabolism
Endocrinology

Cite this

Micossi, P., Scavini, M., Dosio, F., Monti, L., & Piatti, P. M. (1985). Metabolic instability in type I diabetic patients. Studies on insulin absorption, hepatic production of metabolites and glucose counterregulation. Acta Diabetologica Latina, 22(3), 215-221. https://doi.org/10.1007/BF02590772

@article{40bd1d8b26184e7280938ce3009776b8,

title = "Metabolic instability in type I diabetic patients. Studies on insulin absorption, hepatic production of metabolites and glucose counterregulation",

abstract = "In order to investigate the causes underlying metabolic instability in type I diabetes mellitus, we studied 8 unstable (group 1) and 4 well-controlled (group 2) diabetic patients, matched for age and duration of diabetes. Subjects were connected overnight to an artificial pancreas and brought to normoglycemia. On the following morning, insulin administration was discontinued for 6 hours and both metabolic and hormonal studies were carried out during this period. After insulin withdrawal, group 1 showed a faster rise of blood glucose (peak: 324.63±24.93 vs 175.25±42.63 mg/dl, p",

keywords = "Brittle diabetes, C-peptide secretion, Hepatic glucose production, Metabolic instability",

author = "Piero Micossi and Marina Scavini and Flaviano Dosio and Lucilla Monti and Piatti, {Pier Marco}",

year = "1985",

month = jul

doi = "10.1007/BF02590772",

language = "English",

volume = "22",

pages = "215--221",

journal = "Acta Diabetologica",

issn = "0940-5429",

publisher = "Springer-Verlag Italia s.r.l.",

number = "3",

}

TY - JOUR

T1 - Metabolic instability in type I diabetic patients. Studies on insulin absorption, hepatic production of metabolites and glucose counterregulation

AU - Micossi, Piero

AU - Scavini, Marina

AU - Dosio, Flaviano

AU - Monti, Lucilla

AU - Piatti, Pier Marco

PY - 1985/7

Y1 - 1985/7

N2 - In order to investigate the causes underlying metabolic instability in type I diabetes mellitus, we studied 8 unstable (group 1) and 4 well-controlled (group 2) diabetic patients, matched for age and duration of diabetes. Subjects were connected overnight to an artificial pancreas and brought to normoglycemia. On the following morning, insulin administration was discontinued for 6 hours and both metabolic and hormonal studies were carried out during this period. After insulin withdrawal, group 1 showed a faster rise of blood glucose (peak: 324.63±24.93 vs 175.25±42.63 mg/dl, p

AB - In order to investigate the causes underlying metabolic instability in type I diabetes mellitus, we studied 8 unstable (group 1) and 4 well-controlled (group 2) diabetic patients, matched for age and duration of diabetes. Subjects were connected overnight to an artificial pancreas and brought to normoglycemia. On the following morning, insulin administration was discontinued for 6 hours and both metabolic and hormonal studies were carried out during this period. After insulin withdrawal, group 1 showed a faster rise of blood glucose (peak: 324.63±24.93 vs 175.25±42.63 mg/dl, p

KW - Brittle diabetes

KW - C-peptide secretion

KW - Hepatic glucose production

KW - Metabolic instability

UR - http://www.scopus.com/inward/record.url?scp=0022361143&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0022361143&partnerID=8YFLogxK

U2 - 10.1007/BF02590772

DO - 10.1007/BF02590772

M3 - Article

C2 - 3907236

AN - SCOPUS:0022361143

VL - 22

SP - 215

EP - 221

JO - Acta Diabetologica

JF - Acta Diabetologica

SN - 0940-5429

IS - 3

ER -

Access to Document

10.1007/BF02590772