Metabolic mechanisms of cancer-induced inhibition of immune responses

Antonella Viola, Vincenzo Bronte

Research output: Contribution to journalArticlepeer-review

Abstract

During progression, tumors become refractory to the offensive weapons of the immune system. It has been known for a long time that the tumor microenvironment presents a profound modification in the metabolism of arachidonic acid and amino acids such as l-triptophan and l-arginine. However, only in the last decade we have started to appreciate how these changes might cause dysfunctions in cells of both adaptive and innate immune system. The knowledge of these complex and partially interconnected metabolic pathways is offering new targets for an integrated pharmacological approach aiming at freeing tumor-specific T lymphocytes from the latches of cancer influence.

Original languageEnglish
Pages (from-to)309-316
Number of pages8
JournalSeminars in Cancer Biology
Volume17
Issue number4
DOIs
Publication statusPublished - Aug 2007

Keywords

  • Immunosuppression
  • Metabolism
  • T lymphocyte
  • Tumor microenvironment

ASJC Scopus subject areas

  • Cancer Research

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