Metabolic networks classification and knowledge discovery by information granulation

Alessio Martino, Alessandro Giuliani, Virginia Todde, Mariano Bizzarri, Antonello Rizzi

Research output: Contribution to journalArticlepeer-review

Abstract

Graphs are powerful structures able to capture topological and semantic information from data, hence suitable for modelling a plethora of real-world (complex) systems. For this reason, graph-based pattern recognition gained a lot of attention in recent years. In this paper, a general-purpose classification system in the graphs domain is presented. When most of the information of the available patterns can be encoded in edge labels, an information granulation-based approach is highly discriminant and allows for the identification of semantically meaningful edges. The proposed classification system has been tested on the entire set of organisms (5299) for which metabolic networks are known, allowing for both a perfect mirroring of the underlying taxonomy and the identification of most discriminant metabolic reactions and pathways. The widespread diffusion of graph (network) structures in biology makes the proposed pattern recognition approach potentially very useful in many different fields of application. More specifically, the possibility to have a reliable metric to compare different metabolic systems is instrumental in emerging fields like microbiome analysis and, more in general, for proposing metabolic networks as a universal phenotype spanning the entire tree of life and in direct contact with environmental cues.

Original languageEnglish
Article number107187
JournalComputational Biology and Chemistry
Volume84
DOIs
Publication statusPublished - Feb 2020

Keywords

  • Complex networks
  • Computational biology
  • Embedding spaces
  • Granular computing
  • Metabolic pathways
  • Support vector machines

ASJC Scopus subject areas

  • Structural Biology
  • Biochemistry
  • Organic Chemistry
  • Computational Mathematics

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