Metabolic parameters after BloEnterics Intragastric Balloon placement in obese patients

F. Donadio, L. F. Sburlati, B. Masserini, E. M. Lunati, E. Lattuada, M. A. Zappa, E. Mozzi, P. Beck-Peccoz, E. Orsi

Research output: Contribution to journalArticle


Background: BloEnterics Intragastric Balloon (BIB®) is a non-invasive, temporary and relatively safe procedure shown to be effective in the short-term treatment of obesity. Nowadays, BIB® does not show convincing evidence of significant long-term weight loss, as compared with conventional management, and data regarding changes in metabolic and nutritional parameters are lacking. Methods: Forty obese patients [11 males, 29 females, age 36.65±10.6 yr, body mass index (BMI) 44.9±8.9 kg/m 2] were evaluated before and 3 and 6 months after BIB® placement by assessment of anthropometric and biochemical parameters as well as nutritional habits. Results: Patients showed a significant reduction in weight (-132±65%), BMI (-13.2%), waist circumference (-6.5 cm), and percentage of fat mass (-19.5%), but not fat-free mass. A significant improvement in insulin sensitivity but not in lipid pattern was seen. After BIB® insertion, a significant reduction in caloric intake was paralleled by a redistribution of nutrients; in particular, increased lipid (12.8%) and decreased carbohydrate (-11.7%) percentage, but not absolute intake was observed. Conclusion: These data show that BIB® improves anthropometric parameters, with reduction of fat mass and preservation of fat-free mass, as well as insulin resistance, but not other metabolic features. The observed change in dietary habits, with a relative increase in lipid intake, once BIB® is removed, might favor body weight regain and impact negatively on body weight composition and the other traits of the metabolic syndrome. (J. Endocrinol. Invest. 32: 165-168, 2009)

Original languageEnglish
Pages (from-to)165-168
Number of pages4
JournalJournal of Endocrinological Investigation
Issue number2
Publication statusPublished - Feb 2009


  • BIB®
  • Cardiovascular risk
  • Fat mass
  • Fat-free mass
  • Insulin-resistance
  • Nutritional habits
  • Obesity
  • Weight loss

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Endocrinology

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    Donadio, F., Sburlati, L. F., Masserini, B., Lunati, E. M., Lattuada, E., Zappa, M. A., Mozzi, E., Beck-Peccoz, P., & Orsi, E. (2009). Metabolic parameters after BloEnterics Intragastric Balloon placement in obese patients. Journal of Endocrinological Investigation, 32(2), 165-168.