Metabolic parameters and adipokine profile in growth hormone deficient (GHD) children before and after 12-month GH treatment

C. Meazza, H. H. Elsedfy, S. Pagani, E. Bozzola, M. El Kholy, M. Bozzola

Research output: Contribution to journalArticle

Abstract

It is a common knowledge that GH exhibits a large number of metabolic effects, involving lipid and glucose homeostasis. The aim of the study was to investigate the effect of one year GH therapy on metabolic parameters and adipokines in GH deficient (GHD) children. Sixteen prepubertal children (11 M and 5 F) with complete GHD (age range: 3.4-14.7 years) and 20 (13 M and 7 F) age and sex-matched healthy children (age range: 4.6-12.3 years) were studied. Blood was collected from patients before starting GH therapy (0.025 mg/kg/day) and one year later, and from healthy children to measure adiponectin, leptin, osteoprotegerin, resistin, interleukin (IL)-6, tumor necrosis factor (TNF)-α levels, and other glucose and lipid metabolism parameters. Adiponectin and resistin levels were significantly higher (49 980 ng/ml vs. 14 790 ng/ml and 11.0 pg/ml vs. 6.3, respectively) in GHD children before GH therapy than in controls. Serum IGF-I levels (p=0.0001) and height SDS (p

Original languageEnglish
Pages (from-to)219-223
Number of pages5
JournalHormone and Metabolic Research
Volume46
Issue number3
DOIs
Publication statusPublished - 2014

Keywords

  • adipokines
  • children
  • GH deficiency
  • GH therapy
  • metabolism

ASJC Scopus subject areas

  • Biochemistry
  • Endocrinology
  • Clinical Biochemistry
  • Biochemistry, medical
  • Endocrinology, Diabetes and Metabolism

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