Metabolic pathways regulated by p63

Eleonora Candi, Artem Smirnov, Emanuele Panatta, Anna Maria Lena, Flavia Novelli, Maria Cristina Piro, Mara Mancini, Margherita Maria Annicchiarico Petruzzelli, Gerry Melino

Research output: Contribution to journalReview article

Abstract

The transcription factor p63 belongs to the p53-family and is a master regulator of proliferative potential, lineage specification, and differentiation in epithelia during development and tissue homeostasis. In cancer, p63 contribution is isoform-specific, with both oncogenic and tumour suppressive roles attributed, for ΔNp63 and TAp63, respectively. Recently, p53 and TAp73, in line with other tumour suppressor genes, have emerged as important regulators of energy metabolism and metabolic reprogramming in cancer. To date, p63 contributions in controlling energy metabolism have been partially investigated; given the extensive interaction of the p53 family members, these studies have potential implications in tumour cells for metabolic reprogramming. Here, we review the role of p63 isoforms, TAp63 and ΔNp63, in controlling cell metabolism, focusing on their specific metabolic target genes and their physiological/functional context of action.

Original languageEnglish
Pages (from-to)440-444
Number of pages5
JournalBiochemical and Biophysical Research Communications
Volume482
Issue number3
DOIs
Publication statusPublished - Jan 15 2017

Keywords

  • Glycolysis
  • Metabolism
  • p53 family
  • p63

ASJC Scopus subject areas

  • Biophysics
  • Biochemistry
  • Molecular Biology
  • Cell Biology

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  • Cite this

    Candi, E., Smirnov, A., Panatta, E., Lena, A. M., Novelli, F., Piro, M. C., Mancini, M., Annicchiarico Petruzzelli, M. M., & Melino, G. (2017). Metabolic pathways regulated by p63. Biochemical and Biophysical Research Communications, 482(3), 440-444. https://doi.org/10.1016/j.bbrc.2016.10.094