Metabolic remodeling in skeletal muscle atrophy as a therapeutic target

Alessandra Renzini, Carles Sánchez Riera, Isidora Minic, Chiara D’ercole, Biliana Lozanoska‐ochser, Alessia Cedola, Giuseppe Gigli, Viviana Moresi, Luca Madaro

Research output: Contribution to journalReview articlepeer-review


Skeletal muscle is a highly responsive tissue, able to remodel its size and metabolism in response to external demand. Muscle fibers can vary from fast glycolytic to slow oxidative, and their frequency in a specific muscle is tightly regulated by fiber maturation, innervation, or external causes. Atrophic conditions, including aging, amyotrophic lateral sclerosis, and cancer‐induced cachexia, differ in the causative factors and molecular signaling leading to muscle wasting; nevertheless, all of these conditions are characterized by metabolic remodeling, which contributes to the pathological progression of muscle atrophy. Here, we discuss how changes in muscle metabolism can be used as a therapeutic target and review the evidence in support of nutritional interventions and/or physical exercise as tools for counteracting muscle wasting in atrophic conditions.

Original languageEnglish
Article number517
Issue number8
Publication statusPublished - Aug 2021


  • Diet
  • Epigenetics
  • Muscle wasting
  • Physical exercise
  • Skeletal muscle metabolism

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Biochemistry
  • Molecular Biology


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