Metabolic susceptibility to cancer

M. Taningher, D. Malacarne, D. Ugolini, A. Perrotta, S. Parodi

Research output: Contribution to journalArticle

Abstract

Recently, several molecular genetic bases of polymorphic enzyme activities involved in drug activation and detoxification have been elucidated. A great deal of data indicate that these enzymes may be involved in carcinogenesis, thus suggesting a relationship between genetic polymorphisms and different susceptibilities to ties malignancies. The most relevant enzymes in question are some P450 cytochromes (mainly the two encoded by CYP1A1 and CYP2D6 genes), glutathione S-transferases (mainly M1 and T1) and N-acetyltransferases (1 and 2). In view of this, we have examined and commented on 24 randomly selected works from the last three years' literature which we assumed to be representative of recent findings on the relationship between genetic polymorphisms and metabolic susceptibility to cancer. We conclude that, while at the level of basic research we are improving our capabilities of matching levels of exposure with individual susceptibility factors, and thus increasingly acquiring better means to assess individual cancer risks, applications at the level of individual counselling are still at their inception.

Original languageEnglish
Pages (from-to)42-47
Number of pages6
JournalFORUM - Trends in Experimental and Clinical Medicine
Volume7
Issue number1 SUPPL. 2
Publication statusPublished - 1997

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Keywords

  • Cancer risk
  • Chemical carcinogenesis
  • Drug metabolism
  • Genetic polymorphism

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Taningher, M., Malacarne, D., Ugolini, D., Perrotta, A., & Parodi, S. (1997). Metabolic susceptibility to cancer. FORUM - Trends in Experimental and Clinical Medicine, 7(1 SUPPL. 2), 42-47.