Metabolic syndrome, abdominal obesity, and cardiovascular risk in elderly women

Marcos A S Cabrera, Otávio C E Gebara, Jayme Diament, Amit Nussbacher, Giuseppe Rosano, Maurício Wajngarten

Research output: Contribution to journalArticle

Abstract

Background: Metabolic syndrome and abdominal obesity are risk factors for cardiovascular diseases in middle age women but, not completely understood in older people. In this study we analyzed the association between metabolic syndrome and abdominal obesity and the occurrence of cardiovascular events in these elderly women. Methods: A prospective follow-up study included 516 consecutive women aged 60-84 years who sought medical care at a geriatric outpatient facility. The presence of metabolic syndrome and higher quartiles of waist circumference and waist-to-hip ratio were analyzed as predictive variables, and were adjusted for age, smoking, and previous cardiovascular diseases. The outcomes were the occurrence of stroke, myocardial infarction, evidence of coronary artery disease, or cardiovascular death. Results: During a mean follow-up of 6.6 years, 94 (18.2%) cardiovascular events were observed (48 fatal and 46 non-fatal). Metabolic syndrome was diagnosed in 206 women (39.9%). After adjustments for confounding variables, metabolic syndrome and waist-to-hip ratio above the 75th percentile (> 0.98) were predictors of the outcomes, but greater waist circumference (> 96 cm) was not. Adjusted hazard ratios for these variables were: metabolic syndrome, 1.66, 95% CI - 1.11 to 2.47, p = 0.01; waist-to-hip ratio, 1.72, 95% CI - 1.05 to 2.82; p = 0.03 and waist circumference, 1.37, 95% CI - 0.91 to 2.07, p = 0.12. Conclusion: Metabolic syndrome and high waist-to-hip ratio were associated with increased risk of cardiovascular events in the studied sample.

Original languageEnglish
Pages (from-to)224-229
Number of pages6
JournalInternational Journal of Cardiology
Volume114
Issue number2
DOIs
Publication statusPublished - Jan 8 2007

Fingerprint

Metabolic Syndrome X
Abdominal Obesity
Waist-Hip Ratio
Waist Circumference
Cardiovascular Diseases
Confounding Factors (Epidemiology)
Geriatrics
Coronary Artery Disease
Outpatients
Smoking
Stroke
Myocardial Infarction

Keywords

  • Abdominal obesity
  • Cardiovascular diseases
  • Elderly
  • Metabolic syndrome

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Cite this

Metabolic syndrome, abdominal obesity, and cardiovascular risk in elderly women. / Cabrera, Marcos A S; Gebara, Otávio C E; Diament, Jayme; Nussbacher, Amit; Rosano, Giuseppe; Wajngarten, Maurício.

In: International Journal of Cardiology, Vol. 114, No. 2, 08.01.2007, p. 224-229.

Research output: Contribution to journalArticle

Cabrera, Marcos A S ; Gebara, Otávio C E ; Diament, Jayme ; Nussbacher, Amit ; Rosano, Giuseppe ; Wajngarten, Maurício. / Metabolic syndrome, abdominal obesity, and cardiovascular risk in elderly women. In: International Journal of Cardiology. 2007 ; Vol. 114, No. 2. pp. 224-229.
@article{4b237a4b3c934d35b4e0a0d70e667195,
title = "Metabolic syndrome, abdominal obesity, and cardiovascular risk in elderly women",
abstract = "Background: Metabolic syndrome and abdominal obesity are risk factors for cardiovascular diseases in middle age women but, not completely understood in older people. In this study we analyzed the association between metabolic syndrome and abdominal obesity and the occurrence of cardiovascular events in these elderly women. Methods: A prospective follow-up study included 516 consecutive women aged 60-84 years who sought medical care at a geriatric outpatient facility. The presence of metabolic syndrome and higher quartiles of waist circumference and waist-to-hip ratio were analyzed as predictive variables, and were adjusted for age, smoking, and previous cardiovascular diseases. The outcomes were the occurrence of stroke, myocardial infarction, evidence of coronary artery disease, or cardiovascular death. Results: During a mean follow-up of 6.6 years, 94 (18.2{\%}) cardiovascular events were observed (48 fatal and 46 non-fatal). Metabolic syndrome was diagnosed in 206 women (39.9{\%}). After adjustments for confounding variables, metabolic syndrome and waist-to-hip ratio above the 75th percentile (> 0.98) were predictors of the outcomes, but greater waist circumference (> 96 cm) was not. Adjusted hazard ratios for these variables were: metabolic syndrome, 1.66, 95{\%} CI - 1.11 to 2.47, p = 0.01; waist-to-hip ratio, 1.72, 95{\%} CI - 1.05 to 2.82; p = 0.03 and waist circumference, 1.37, 95{\%} CI - 0.91 to 2.07, p = 0.12. Conclusion: Metabolic syndrome and high waist-to-hip ratio were associated with increased risk of cardiovascular events in the studied sample.",
keywords = "Abdominal obesity, Cardiovascular diseases, Elderly, Metabolic syndrome",
author = "Cabrera, {Marcos A S} and Gebara, {Ot{\'a}vio C E} and Jayme Diament and Amit Nussbacher and Giuseppe Rosano and Maur{\'i}cio Wajngarten",
year = "2007",
month = "1",
day = "8",
doi = "10.1016/j.ijcard.2006.01.019",
language = "English",
volume = "114",
pages = "224--229",
journal = "International Journal of Cardiology",
issn = "0167-5273",
publisher = "Elsevier Ireland Ltd",
number = "2",

}

TY - JOUR

T1 - Metabolic syndrome, abdominal obesity, and cardiovascular risk in elderly women

AU - Cabrera, Marcos A S

AU - Gebara, Otávio C E

AU - Diament, Jayme

AU - Nussbacher, Amit

AU - Rosano, Giuseppe

AU - Wajngarten, Maurício

PY - 2007/1/8

Y1 - 2007/1/8

N2 - Background: Metabolic syndrome and abdominal obesity are risk factors for cardiovascular diseases in middle age women but, not completely understood in older people. In this study we analyzed the association between metabolic syndrome and abdominal obesity and the occurrence of cardiovascular events in these elderly women. Methods: A prospective follow-up study included 516 consecutive women aged 60-84 years who sought medical care at a geriatric outpatient facility. The presence of metabolic syndrome and higher quartiles of waist circumference and waist-to-hip ratio were analyzed as predictive variables, and were adjusted for age, smoking, and previous cardiovascular diseases. The outcomes were the occurrence of stroke, myocardial infarction, evidence of coronary artery disease, or cardiovascular death. Results: During a mean follow-up of 6.6 years, 94 (18.2%) cardiovascular events were observed (48 fatal and 46 non-fatal). Metabolic syndrome was diagnosed in 206 women (39.9%). After adjustments for confounding variables, metabolic syndrome and waist-to-hip ratio above the 75th percentile (> 0.98) were predictors of the outcomes, but greater waist circumference (> 96 cm) was not. Adjusted hazard ratios for these variables were: metabolic syndrome, 1.66, 95% CI - 1.11 to 2.47, p = 0.01; waist-to-hip ratio, 1.72, 95% CI - 1.05 to 2.82; p = 0.03 and waist circumference, 1.37, 95% CI - 0.91 to 2.07, p = 0.12. Conclusion: Metabolic syndrome and high waist-to-hip ratio were associated with increased risk of cardiovascular events in the studied sample.

AB - Background: Metabolic syndrome and abdominal obesity are risk factors for cardiovascular diseases in middle age women but, not completely understood in older people. In this study we analyzed the association between metabolic syndrome and abdominal obesity and the occurrence of cardiovascular events in these elderly women. Methods: A prospective follow-up study included 516 consecutive women aged 60-84 years who sought medical care at a geriatric outpatient facility. The presence of metabolic syndrome and higher quartiles of waist circumference and waist-to-hip ratio were analyzed as predictive variables, and were adjusted for age, smoking, and previous cardiovascular diseases. The outcomes were the occurrence of stroke, myocardial infarction, evidence of coronary artery disease, or cardiovascular death. Results: During a mean follow-up of 6.6 years, 94 (18.2%) cardiovascular events were observed (48 fatal and 46 non-fatal). Metabolic syndrome was diagnosed in 206 women (39.9%). After adjustments for confounding variables, metabolic syndrome and waist-to-hip ratio above the 75th percentile (> 0.98) were predictors of the outcomes, but greater waist circumference (> 96 cm) was not. Adjusted hazard ratios for these variables were: metabolic syndrome, 1.66, 95% CI - 1.11 to 2.47, p = 0.01; waist-to-hip ratio, 1.72, 95% CI - 1.05 to 2.82; p = 0.03 and waist circumference, 1.37, 95% CI - 0.91 to 2.07, p = 0.12. Conclusion: Metabolic syndrome and high waist-to-hip ratio were associated with increased risk of cardiovascular events in the studied sample.

KW - Abdominal obesity

KW - Cardiovascular diseases

KW - Elderly

KW - Metabolic syndrome

UR - http://www.scopus.com/inward/record.url?scp=33751208889&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=33751208889&partnerID=8YFLogxK

U2 - 10.1016/j.ijcard.2006.01.019

DO - 10.1016/j.ijcard.2006.01.019

M3 - Article

C2 - 16784787

AN - SCOPUS:33751208889

VL - 114

SP - 224

EP - 229

JO - International Journal of Cardiology

JF - International Journal of Cardiology

SN - 0167-5273

IS - 2

ER -