Metabolic syndrome affects breast-cancer risk in postmenopausal women: National Cancer Institute of Naples experience

Immacolata Capasso, Emanuela Esposito, Francesca Pentimalli, Anna Crispo, Maurizio Montella, Maria Grimaldi, Mariarosaria De Marco, Ernestina Cavalcanti, Massimiliano D'Aiuto, Alfredo Fucito, Giuseppe Frasci, Nicola Maurea, Giuseppe Esposito, Tonino Pedicini, Aldo Vecchione, Giuseppe D'Aiuto, Antonio Giordano

Research output: Contribution to journalArticle

Abstract

Postmenopausal women show the highest incidence of breast cancer in the female population and are often affected by metabolic syndrome. Metabolic syndrome (MS)-characterized by central adiposity, insulin resistance, low serum high-density lipoprotein cholesterol (HDL-C), high serum triglyceride and high blood pressure-seems to be strictly correlated to breast carcinogenesis. We enrolled 777 healthy women and women with breast cancer in our nested casecontrol study to evaluate the association between MS and breast cancer, analyzing anthropometric parameters (weight, height, BMI, waist and hip circumference), blood pressure, serum HDL-C, triglyceride, fasting plasma glucose, insulin, testosterone and uric acid levels and administering a questionnaire about physical activity, food intake, tobacco use, alcohol abuse, personal and familial history of disease. We found an higher prevalence of metabolic syndrome (30%) in postmenopausal breast cancer patients compared to healthy women (19%). None of the individual MS features was strong enough to be considered responsible for breast carcinogenesis alone. However, of the 63 postmenopausal breast cancer cases associated to MS, 30% presented three or more MS features, suggesting that the activation of multiple molecular pathways underlying MS might contribute to tumorigenesis. Our data support the hypothesis that MS may be an indicator of breast cancer risk in postmenopausal women. The unsettlement of the hormonal arrangement in postmenopausal, along with an increase in visceral adiposity, probably favour the hormone-dependent cell proliferation, which drives tumorigenesis. Adjustments in lifestyle with physical activity intensification and healthy diet could represent modifiable factors for the primary prevention of sporadic breast cancer.

Original languageEnglish
Pages (from-to)1240-1243
Number of pages4
JournalCancer Biology and Therapy
Volume10
Issue number12
DOIs
Publication statusPublished - Dec 15 2010

Keywords

  • Body mass index
  • Breast cancer
  • High-density lipoprotein cholesterol (HDL-C)
  • Hyperandrogenic status
  • Hyperinsulinemia
  • Insulin resistance
  • Insulin-like growth factor 1 (IGF-1)
  • Metabolic syndrome
  • Postmenopausal
  • Weight gain

ASJC Scopus subject areas

  • Cancer Research
  • Oncology
  • Molecular Medicine
  • Pharmacology

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