Abstract
Postmenopausal women show the highest incidence of breast cancer in the female population and are often affected by metabolic syndrome. Metabolic syndrome (MS)-characterized by central adiposity, insulin resistance, low serum high-density lipoprotein cholesterol (HDL-C), high serum triglyceride and high blood pressure-seems to be strictly correlated to breast carcinogenesis. We enrolled 777 healthy women and women with breast cancer in our nested casecontrol study to evaluate the association between MS and breast cancer, analyzing anthropometric parameters (weight, height, BMI, waist and hip circumference), blood pressure, serum HDL-C, triglyceride, fasting plasma glucose, insulin, testosterone and uric acid levels and administering a questionnaire about physical activity, food intake, tobacco use, alcohol abuse, personal and familial history of disease. We found an higher prevalence of metabolic syndrome (30%) in postmenopausal breast cancer patients compared to healthy women (19%). None of the individual MS features was strong enough to be considered responsible for breast carcinogenesis alone. However, of the 63 postmenopausal breast cancer cases associated to MS, 30% presented three or more MS features, suggesting that the activation of multiple molecular pathways underlying MS might contribute to tumorigenesis. Our data support the hypothesis that MS may be an indicator of breast cancer risk in postmenopausal women. The unsettlement of the hormonal arrangement in postmenopausal, along with an increase in visceral adiposity, probably favour the hormone-dependent cell proliferation, which drives tumorigenesis. Adjustments in lifestyle with physical activity intensification and healthy diet could represent modifiable factors for the primary prevention of sporadic breast cancer.
| Original language | English |
|---|---|
| Pages (from-to) | 1240-1243 |
| Number of pages | 4 |
| Journal | Cancer Biology and Therapy |
| Volume | 10 |
| Issue number | 12 |
| DOIs | |
| Publication status | Published - Dec 15 2010 |
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Keywords
- Body mass index
- Breast cancer
- High-density lipoprotein cholesterol (HDL-C)
- Hyperandrogenic status
- Hyperinsulinemia
- Insulin resistance
- Insulin-like growth factor 1 (IGF-1)
- Metabolic syndrome
- Postmenopausal
- Weight gain
ASJC Scopus subject areas
- Cancer Research
- Oncology
- Molecular Medicine
- Pharmacology
Cite this
Metabolic syndrome affects breast-cancer risk in postmenopausal women : National Cancer Institute of Naples experience. / Capasso, Immacolata; Esposito, Emanuela; Pentimalli, Francesca; Crispo, Anna; Montella, Maurizio; Grimaldi, Maria; De Marco, Mariarosaria; Cavalcanti, Ernestina; D'Aiuto, Massimiliano; Fucito, Alfredo; Frasci, Giuseppe; Maurea, Nicola; Esposito, Giuseppe; Pedicini, Tonino; Vecchione, Aldo; D'Aiuto, Giuseppe; Giordano, Antonio.
In: Cancer Biology and Therapy, Vol. 10, No. 12, 15.12.2010, p. 1240-1243.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Metabolic syndrome affects breast-cancer risk in postmenopausal women
T2 - National Cancer Institute of Naples experience
AU - Capasso, Immacolata
AU - Esposito, Emanuela
AU - Pentimalli, Francesca
AU - Crispo, Anna
AU - Montella, Maurizio
AU - Grimaldi, Maria
AU - De Marco, Mariarosaria
AU - Cavalcanti, Ernestina
AU - D'Aiuto, Massimiliano
AU - Fucito, Alfredo
AU - Frasci, Giuseppe
AU - Maurea, Nicola
AU - Esposito, Giuseppe
AU - Pedicini, Tonino
AU - Vecchione, Aldo
AU - D'Aiuto, Giuseppe
AU - Giordano, Antonio
PY - 2010/12/15
Y1 - 2010/12/15
N2 - Postmenopausal women show the highest incidence of breast cancer in the female population and are often affected by metabolic syndrome. Metabolic syndrome (MS)-characterized by central adiposity, insulin resistance, low serum high-density lipoprotein cholesterol (HDL-C), high serum triglyceride and high blood pressure-seems to be strictly correlated to breast carcinogenesis. We enrolled 777 healthy women and women with breast cancer in our nested casecontrol study to evaluate the association between MS and breast cancer, analyzing anthropometric parameters (weight, height, BMI, waist and hip circumference), blood pressure, serum HDL-C, triglyceride, fasting plasma glucose, insulin, testosterone and uric acid levels and administering a questionnaire about physical activity, food intake, tobacco use, alcohol abuse, personal and familial history of disease. We found an higher prevalence of metabolic syndrome (30%) in postmenopausal breast cancer patients compared to healthy women (19%). None of the individual MS features was strong enough to be considered responsible for breast carcinogenesis alone. However, of the 63 postmenopausal breast cancer cases associated to MS, 30% presented three or more MS features, suggesting that the activation of multiple molecular pathways underlying MS might contribute to tumorigenesis. Our data support the hypothesis that MS may be an indicator of breast cancer risk in postmenopausal women. The unsettlement of the hormonal arrangement in postmenopausal, along with an increase in visceral adiposity, probably favour the hormone-dependent cell proliferation, which drives tumorigenesis. Adjustments in lifestyle with physical activity intensification and healthy diet could represent modifiable factors for the primary prevention of sporadic breast cancer.
AB - Postmenopausal women show the highest incidence of breast cancer in the female population and are often affected by metabolic syndrome. Metabolic syndrome (MS)-characterized by central adiposity, insulin resistance, low serum high-density lipoprotein cholesterol (HDL-C), high serum triglyceride and high blood pressure-seems to be strictly correlated to breast carcinogenesis. We enrolled 777 healthy women and women with breast cancer in our nested casecontrol study to evaluate the association between MS and breast cancer, analyzing anthropometric parameters (weight, height, BMI, waist and hip circumference), blood pressure, serum HDL-C, triglyceride, fasting plasma glucose, insulin, testosterone and uric acid levels and administering a questionnaire about physical activity, food intake, tobacco use, alcohol abuse, personal and familial history of disease. We found an higher prevalence of metabolic syndrome (30%) in postmenopausal breast cancer patients compared to healthy women (19%). None of the individual MS features was strong enough to be considered responsible for breast carcinogenesis alone. However, of the 63 postmenopausal breast cancer cases associated to MS, 30% presented three or more MS features, suggesting that the activation of multiple molecular pathways underlying MS might contribute to tumorigenesis. Our data support the hypothesis that MS may be an indicator of breast cancer risk in postmenopausal women. The unsettlement of the hormonal arrangement in postmenopausal, along with an increase in visceral adiposity, probably favour the hormone-dependent cell proliferation, which drives tumorigenesis. Adjustments in lifestyle with physical activity intensification and healthy diet could represent modifiable factors for the primary prevention of sporadic breast cancer.
KW - Body mass index
KW - Breast cancer
KW - High-density lipoprotein cholesterol (HDL-C)
KW - Hyperandrogenic status
KW - Hyperinsulinemia
KW - Insulin resistance
KW - Insulin-like growth factor 1 (IGF-1)
KW - Metabolic syndrome
KW - Postmenopausal
KW - Weight gain
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UR - http://www.scopus.com/inward/citedby.url?scp=78650334747&partnerID=8YFLogxK
U2 - 10.4161/cbt.10.12.13473
DO - 10.4161/cbt.10.12.13473
M3 - Article
C2 - 20935521
AN - SCOPUS:78650334747
VL - 10
SP - 1240
EP - 1243
JO - Cancer Biology and Therapy
JF - Cancer Biology and Therapy
SN - 1538-4047
IS - 12
ER -