Metabolic syndrome and albuminuria show an additive effect in modulating glomerular filtration rate in patients with Type 2 Diabetes Mellitus

Mauro Cignarelli, Olga Lamacchia, Giada Cardinale, Anna Rauseo, Sandra Mastroianno, Loreto Gesualdo, Salvatore De Cosmo

Research output: Contribution to journalArticle


Background: Although metabolic syndrome (MetSyn) or albuminuria (MA) most often occurs in concomitance in Type 2 Diabetes Mellitus patients (T2DM), their mode of interaction in increasing the risk of low glomerular filtration rate (GFR) has been poorly investigated. Objective: We evaluated in a cohort of 1659 T2DM patients the relationship between MetSyn and MA in modulating the risk for low GFR. The risk of developing low GFR by graded number of MetSyn traits was also evaluated. Methods: This was a cross-sectional study where 1659 T2DM patients were studied. Low GFR was defined as estimated-GFR (e-GFR) -1 × 1.73 m-2 (modification of diet in renal disease, MDRD, formula). Results: e-GFR progressively decreased from 91 ± 25 of patients MetSyn-MA-, to 82 ± 27 of patients MetSyn-MA+, 81 ± 24 of patients MetSyn+MA- and 76 ± 30 ml min-1 × 1.73 m-2 of patients MetSyn+MA+ (adjusted p <0.0001). A progressive gradient of the frequency of patients with low e-GFR with concomitance of MetSyn and MA was also observed [MetSyn-MA- (6.1%), MetSyn-MA+ (15.3%), MetSyn+MA-(16.6%), MetSyn+MA+ (26.8%); p <0.0001]. As compared to patients with MetSyn-MA-, the risk progressively increased to 2.80 (95% C.I. 1.46-5.37; p = 0.002) in MetSyn+MA-, to 2.83 (95% C.I. 1.12-7.10; p = 0.027) in MetSyn-MA+ and to 5.73 (95% C.I. 2.99-10.9; p <0.0001) in MetSyn+MA+ patients. Estimated-GFR progressively decreased by number of MetSyn traits in the whole population (adjusted p <0.0001). Conclusions: MetSyn or MA has an additive effect in increasing the risk of having low GFR in patients with T2DM. Furthermore, e-GFR is negatively affected by graded number of MetSyn traits independently of albuminuria.

Original languageEnglish
Pages (from-to)139-142
Number of pages4
JournalDiabetes and Metabolic Syndrome: Clinical Research and Reviews
Issue number3
Publication statusPublished - Sep 2009



  • Albuminuria
  • Chronic kidney disease
  • Diabetic nephropathy
  • Metabolic syndrome
  • Renal failure

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Internal Medicine

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