Metabolic syndrome and all-cause mortality in older men and women

Paola Forti, Gian L. Pirazzoli, Benedetta Maltoni, Giampaolo Bianchi, Donatella Magalotti, Antonio Muscari, Erminia Mariani, Giovanni Ravaglia, Marco Zoli

Research output: Contribution to journalArticlepeer-review


Background Prevalence of metabolic syndrome (MetS) increases with age, but its association with all-cause mortality in older persons remains uncertain. This study investigated the association of all-cause mortality with MetS and its individual components in older men and women. Methods A total of 917 men and 1043 women aged 65years and older from two Italian population-based cohorts were included in the study. MetS was defined according to four different definitions: National Cholesterol Education Program (NCEP), NCEP revised according to the American Heart Association and National Heart Lung Blood Institute (NCEP-R), International Diabetes Organization (IDF) and Joint Interim Statement (JIS). All of these definitions include abdominal obesity, hyperglycaemia, hypertriglyceridaemia, low high-density lipoprotein cholesterol and hypertension. Hazard Ratios (HR) and their corresponding 95% confidence interval (95%CI) estimated from multivariable-adjusted Cox regression models were used to investigate the associations of all-cause mortality with baseline MetS status and individual MetS components. Results After 6·5±1·8years of follow-up, there were 179 deaths among women and 193 among men. Mortality risk was increased in women with MetS by any definition, regardless of individual components, but limited to age 70-79years (NCEP, HR=2·02, 95%CI, 1·16-3·53; NCEP-R, HR=2·51, 95%CI, 1·45-4·34; IDF, HR=2·16, 95%CI, 1·26-3·72; JIS, HR=2·16, 95%CI, 1·26-3·72). Mortality risk of men was associated with hypertriglyceridaemia below age 70years (HR=2·50, 95%CI, 1·19-5·25), but unrelated to MetS status. Conclusions Metabolic Syndrome is associated with all-cause mortality in older women but not in men. The association, however, is limited to a narrow age range.

Original languageEnglish
Pages (from-to)1000-1009
Number of pages10
JournalEuropean Journal of Clinical Investigation
Issue number9
Publication statusPublished - Sep 2012


  • All-cause mortality
  • Gender
  • Longitudinal study
  • Metabolic syndrome
  • Older age
  • Risk factor

ASJC Scopus subject areas

  • Medicine(all)
  • Clinical Biochemistry
  • Biochemistry


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