TY - JOUR
T1 - Metabolic syndrome and benign prostatic hyperplasia
T2 - Evidence of a potential relationship, hypothesized etiology, and prevention
AU - Abdollah, Firas
AU - Briganti, Alberto
AU - Suardi, Nazareno
AU - Castiglione, Fabio
AU - Gallina, Andrea
AU - Capitanio, Umberto
AU - Montorsi, Francesco
PY - 2011/8
Y1 - 2011/8
N2 - Benign prostatic hyperplasia (BPH) is highly prevalent in older men and causes substantial adverse effects on health. The pathogenesis of this disease is not totally clear. Recent reports have suggested a possible relationship between metabolic syndrome (MetS) and BPH. Single components of MetS (obesity, dyslipidemia, hypertension, and insulin resistance) as well as the syndrome itself may predispose patients to a higher risk of BPH and lower urinary tract symptoms (LUTS). This may stem from changes in insulin resistance, increased autonomic activity, impaired nitrergic innervation, increased Rho kinase activity, pro-inflammatory status, and changes in sex hormones that occur in association with MetS. However, the exact underlying mechanisms that regulate the potential relationship between MetS and BPH/LUTS still need to be clarified. Increased physical activity and dietary strategies may help in decreasing the incidence of MetS and its impact on BPH/LUTS. However, differences in the definitions used to address the examined predictors and endpoints preclude the possibility of arriving at definitive conclusions.
AB - Benign prostatic hyperplasia (BPH) is highly prevalent in older men and causes substantial adverse effects on health. The pathogenesis of this disease is not totally clear. Recent reports have suggested a possible relationship between metabolic syndrome (MetS) and BPH. Single components of MetS (obesity, dyslipidemia, hypertension, and insulin resistance) as well as the syndrome itself may predispose patients to a higher risk of BPH and lower urinary tract symptoms (LUTS). This may stem from changes in insulin resistance, increased autonomic activity, impaired nitrergic innervation, increased Rho kinase activity, pro-inflammatory status, and changes in sex hormones that occur in association with MetS. However, the exact underlying mechanisms that regulate the potential relationship between MetS and BPH/LUTS still need to be clarified. Increased physical activity and dietary strategies may help in decreasing the incidence of MetS and its impact on BPH/LUTS. However, differences in the definitions used to address the examined predictors and endpoints preclude the possibility of arriving at definitive conclusions.
KW - Insulin resistance
KW - Metabolic syndrome X complications
KW - Obesity complications
KW - Prostatic hyperplasia etiology
KW - Prostatic hyperplasia pathology
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M3 - Article
C2 - 21927696
AN - SCOPUS:80052056031
VL - 52
SP - 507
EP - 516
JO - Korean Journal of Urology
JF - Korean Journal of Urology
SN - 2005-6737
IS - 8
ER -