Metabolic syndrome and benign prostatic hyperplasia: Evidence of a potential relationship, hypothesized etiology, and prevention

Firas Abdollah, Alberto Briganti, Nazareno Suardi, Fabio Castiglione, Andrea Gallina, Umberto Capitanio, Francesco Montorsi

Research output: Contribution to journalArticlepeer-review

Abstract

Benign prostatic hyperplasia (BPH) is highly prevalent in older men and causes substantial adverse effects on health. The pathogenesis of this disease is not totally clear. Recent reports have suggested a possible relationship between metabolic syndrome (MetS) and BPH. Single components of MetS (obesity, dyslipidemia, hypertension, and insulin resistance) as well as the syndrome itself may predispose patients to a higher risk of BPH and lower urinary tract symptoms (LUTS). This may stem from changes in insulin resistance, increased autonomic activity, impaired nitrergic innervation, increased Rho kinase activity, pro-inflammatory status, and changes in sex hormones that occur in association with MetS. However, the exact underlying mechanisms that regulate the potential relationship between MetS and BPH/LUTS still need to be clarified. Increased physical activity and dietary strategies may help in decreasing the incidence of MetS and its impact on BPH/LUTS. However, differences in the definitions used to address the examined predictors and endpoints preclude the possibility of arriving at definitive conclusions.

Original languageEnglish
Pages (from-to)507-516
Number of pages10
JournalKorean Journal of Urology
Volume52
Issue number8
Publication statusPublished - Aug 2011

Keywords

  • Insulin resistance
  • Metabolic syndrome X complications
  • Obesity complications
  • Prostatic hyperplasia etiology
  • Prostatic hyperplasia pathology

ASJC Scopus subject areas

  • Urology

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