TY - JOUR
T1 - Metabolic syndrome and chronic kidney disease in high-risk Italian hypertensive patients
T2 - The I-DEMAND study
AU - Leoncini, Giovanna
AU - Viazzi, Francesca
AU - Rosei, Enrico Agabiti
AU - Ambrosioni, Ettore
AU - Costa, Francesco Vittorio
AU - Leonetti, Gastone
AU - Pessina, Achille Cesare
AU - Trimarco, Bruno
AU - Volpe, Massimo
AU - Deferrari, Giacomo
AU - Pontremoli, Roberto
PY - 2012/2
Y1 - 2012/2
N2 - Background. Metabolic syndrome (MS) and chronic kidney disease (CKD) are well-known, independent predictors of increased cardiovascular risk. Both conditions are fairly prevalent in the general population. The aim of this study was to assess the relationship between MS or its individual components and CKD in an Italian population of hypertensive patients with normal or mildly to moderately impaired renal function under specialist care. Methods. A total of 2,916 patients (mean age 62 ± 11 years) among those enrolled in the I-DEMAND study were taken into consideration for this analysis. MS was defined according to the NCEP-ATP III criteria. CKD was defined as an estimated GFR (abbreviated MDRD equation) 2 or as the presence of microalbuminuria (mean albumin-to-creatinine ratio ≥2.5 mg/mmol in men and ≥3.5 mg/mmol in women). Results. MS was present in 59% of our study patients. The prevalence of microalbuminuria, reduced GFR and CKD was 26%, 25%, and 41%, respectively. Patients with MS had higher urinary albumin excretion (p
AB - Background. Metabolic syndrome (MS) and chronic kidney disease (CKD) are well-known, independent predictors of increased cardiovascular risk. Both conditions are fairly prevalent in the general population. The aim of this study was to assess the relationship between MS or its individual components and CKD in an Italian population of hypertensive patients with normal or mildly to moderately impaired renal function under specialist care. Methods. A total of 2,916 patients (mean age 62 ± 11 years) among those enrolled in the I-DEMAND study were taken into consideration for this analysis. MS was defined according to the NCEP-ATP III criteria. CKD was defined as an estimated GFR (abbreviated MDRD equation) 2 or as the presence of microalbuminuria (mean albumin-to-creatinine ratio ≥2.5 mg/mmol in men and ≥3.5 mg/mmol in women). Results. MS was present in 59% of our study patients. The prevalence of microalbuminuria, reduced GFR and CKD was 26%, 25%, and 41%, respectively. Patients with MS had higher urinary albumin excretion (p
KW - Albuminuria
KW - Chronic kidney disease
KW - Glomerular filtration rate
KW - Hypertension
KW - Metabolic syndrome
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U2 - 10.5301/JN.2011.7752
DO - 10.5301/JN.2011.7752
M3 - Article
C2 - 21534241
AN - SCOPUS:84862256506
VL - 25
SP - 63
EP - 74
JO - Journal of Nephrology
JF - Journal of Nephrology
SN - 1121-8428
IS - 1
ER -