Abstract
A possible role of vascular and lifestyle-related factors was recently proposed for age-related changes of cognitive function, predementia syndromes, and cognitive decline of degenerative (Alzheimer's disease, AD) or vascular origin (vascular dementia, VaD). At present, cumulative evidence suggests that vascular risk factors may be important in the development of mild cognitive impairment (MCI), dementia, and AD. Among vascular-related factors, metabolic syndrome (MetS) has been associated with the risk of cognitive decline, overall dementia, and VaD, but contrasting findings also existed on the possible role of MetS in AD. If MetS is associated with increased risk of developing cognitive impairment, regardless of mechanism, then early identification and treatment of these individuals at risk might offer new avenues for disease-course modification. Strategies towards early and effective risk factor management could be of value in reducing risk of metabolic and cognitive decline. Future research is needed to confirm the association between MetS and cognitive impairment and to determine the exact mechanism linking them. Such would provide important insights into the causes and interdependencies of predementia and dementia syndromes, and inspire novel strategies for treating and preventing these disorders. At present, vascular risk factor and MetS management could be employed to delay the onset of dementia syndromes or to prevent the progression of predementia syndromes. In the future, trials could be undertaken to determine whether modifications of these risk factors, including inflammation, could lower risk of developing cognitive decline.
| Original language | English |
|---|---|
| Pages (from-to) | 691-724 |
| Number of pages | 34 |
| Journal | Journal of Alzheimer's Disease |
| Volume | 21 |
| Issue number | 3 |
| DOIs | |
| Publication status | Published - 2010 |
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Keywords
- Alzheimer's disease
- dementia
- diabetes mellitus
- HDL cholesterol
- hypertension
- hypertriglyceridemia
- metabolic syndrome
- mild cognitive impairment
- obesity
- predementia syndromes
- vascular dementia
- vascular risk factors
ASJC Scopus subject areas
- Psychiatry and Mental health
- Geriatrics and Gerontology
- Clinical Psychology
Cite this
Metabolic syndrome and cognitive impairment : Current epidemiology and possible underlying mechanisms. / Panza, Francesco; Frisardi, Vincenza; Capurso, Cristiano; Imbimbo, Bruno P.; Vendemiale, Gianluigi; Santamato, Andrea; D'Onofrio, Grazia; Seripa, Davide; Sancarlo, Daniele; Pilotto, Alberto; Solfrizzi, Vincenzo.
In: Journal of Alzheimer's Disease, Vol. 21, No. 3, 2010, p. 691-724.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Metabolic syndrome and cognitive impairment
T2 - Current epidemiology and possible underlying mechanisms
AU - Panza, Francesco
AU - Frisardi, Vincenza
AU - Capurso, Cristiano
AU - Imbimbo, Bruno P.
AU - Vendemiale, Gianluigi
AU - Santamato, Andrea
AU - D'Onofrio, Grazia
AU - Seripa, Davide
AU - Sancarlo, Daniele
AU - Pilotto, Alberto
AU - Solfrizzi, Vincenzo
PY - 2010
Y1 - 2010
N2 - A possible role of vascular and lifestyle-related factors was recently proposed for age-related changes of cognitive function, predementia syndromes, and cognitive decline of degenerative (Alzheimer's disease, AD) or vascular origin (vascular dementia, VaD). At present, cumulative evidence suggests that vascular risk factors may be important in the development of mild cognitive impairment (MCI), dementia, and AD. Among vascular-related factors, metabolic syndrome (MetS) has been associated with the risk of cognitive decline, overall dementia, and VaD, but contrasting findings also existed on the possible role of MetS in AD. If MetS is associated with increased risk of developing cognitive impairment, regardless of mechanism, then early identification and treatment of these individuals at risk might offer new avenues for disease-course modification. Strategies towards early and effective risk factor management could be of value in reducing risk of metabolic and cognitive decline. Future research is needed to confirm the association between MetS and cognitive impairment and to determine the exact mechanism linking them. Such would provide important insights into the causes and interdependencies of predementia and dementia syndromes, and inspire novel strategies for treating and preventing these disorders. At present, vascular risk factor and MetS management could be employed to delay the onset of dementia syndromes or to prevent the progression of predementia syndromes. In the future, trials could be undertaken to determine whether modifications of these risk factors, including inflammation, could lower risk of developing cognitive decline.
AB - A possible role of vascular and lifestyle-related factors was recently proposed for age-related changes of cognitive function, predementia syndromes, and cognitive decline of degenerative (Alzheimer's disease, AD) or vascular origin (vascular dementia, VaD). At present, cumulative evidence suggests that vascular risk factors may be important in the development of mild cognitive impairment (MCI), dementia, and AD. Among vascular-related factors, metabolic syndrome (MetS) has been associated with the risk of cognitive decline, overall dementia, and VaD, but contrasting findings also existed on the possible role of MetS in AD. If MetS is associated with increased risk of developing cognitive impairment, regardless of mechanism, then early identification and treatment of these individuals at risk might offer new avenues for disease-course modification. Strategies towards early and effective risk factor management could be of value in reducing risk of metabolic and cognitive decline. Future research is needed to confirm the association between MetS and cognitive impairment and to determine the exact mechanism linking them. Such would provide important insights into the causes and interdependencies of predementia and dementia syndromes, and inspire novel strategies for treating and preventing these disorders. At present, vascular risk factor and MetS management could be employed to delay the onset of dementia syndromes or to prevent the progression of predementia syndromes. In the future, trials could be undertaken to determine whether modifications of these risk factors, including inflammation, could lower risk of developing cognitive decline.
KW - Alzheimer's disease
KW - dementia
KW - diabetes mellitus
KW - HDL cholesterol
KW - hypertension
KW - hypertriglyceridemia
KW - metabolic syndrome
KW - mild cognitive impairment
KW - obesity
KW - predementia syndromes
KW - vascular dementia
KW - vascular risk factors
UR - http://www.scopus.com/inward/record.url?scp=77957289008&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=77957289008&partnerID=8YFLogxK
U2 - 10.3233/JAD-2010-091669
DO - 10.3233/JAD-2010-091669
M3 - Article
C2 - 20571214
AN - SCOPUS:77957289008
VL - 21
SP - 691
EP - 724
JO - Journal of Alzheimer's Disease
JF - Journal of Alzheimer's Disease
SN - 1387-2877
IS - 3
ER -