Metabolic syndrome and risks of colon and rectal cancer: The european prospective investigation into cancer and nutrition study

Krasimira Aleksandrova, Heiner Boeing, Mazda Jenab, H. Bas Bueno-de-Mesquita, Eugene Jansen, Fran̈zel J B Van Duijnhoven, Veronika Fedirko, Sabina Rinaldi, Isabelle Romieu, Elio Riboli, Dora Romaguera, Kim Overvad, Jane Nautrup Østergaard, Anja Olsen, Anne Tjnøneland, Marie Christine Boutron-Ruault, Franco̧ise Clavel-Chapelon, Sophie Morois, Giovanna Masala, Claudia AgnoliSalvatore Panico, Rosario Tumino, Paolo Vineis, Rudolf Kaaks, Annekatrin Lukanova, Antonia Trichopoulou, Androniki Naska, Christina Bamia, Petra H. Peeters, Laudina Rodriǵuez, Genevieve Buckland, Mariá José Sańchez, Miren Dorronsoro, Jose Mariá Huerta, Aurelio Barricarte, Gor̈an Hallmans, Richard Palmqvist, Kay Tee Khaw, Nicholas Wareham, Naomi E. Allen, Konstantinos K. Tsilidis, Tobias Pischon

Research output: Contribution to journalArticle

Abstract

Metabolic syndrome (MetS) is purportedly related to risk of developing colorectal cancer; however, the association of MetS, as defined according to recent international criteria, and colorectal cancer has not been yet evaluated. In particular, it remains unclear to what extent the MetS components individually account for such an association. We addressed these issues in a nested case-control study that included 1,093 incident cases matched (1:1) to controls by using incidence density sampling. Conditional logistic regression was used to estimate relative risks (RR) and 95% CIs. MetS was defined according to the criteria of the National Cholesterol Education Program/Adult Treatment Panel III (NCEP/ATPIII), the International Diabetes Federation (IDF), and the 2009 harmonized definition. Among individual components, abdominal obesity (RR = 1.51; 95% CI: 1.16-1.96) was associated with colon cancer, whereas abnormal glucose metabolism was associated with both colon (RR = 2.05; 95% CI: 1.57-2.68) and rectal cancer (RR = 2.07; 95% CI: 1.45-2.96). MetS, as defined by each of the definitions, was similarly associated with colon cancer (e.g., RR = 1.91; 95% CI: 1.47-2.42 for MetS by NCEP/ATPIII), whereas MetS by NCEP/ATPIII, but not IDF or harmonized definition, was associated with rectal cancer (RR = 1.45; 95% CI: 1.02-2.06). Overall, these associations were stronger in women than in men. However, the association between MetS and colorectal cancer was accounted for by abdominal obesity and abnormal glucose metabolism such that MetS did not provide risk information beyond these components (likelihood ratio test P = 0.10 for MetS by NCEP/ ATPIII). These data suggest that simple assessment of abnormal glucose metabolism and/or abdominal obesity to identify individuals at colorectal cancer risk may have higher clinical utility than applying more complex MetS definitions.

Original languageEnglish
Pages (from-to)1873-1883
Number of pages11
JournalCancer Prevention Research
Volume4
Issue number11
DOIs
Publication statusPublished - Nov 2011

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Rectal Neoplasms
Colonic Neoplasms
Neoplasms
Abdominal Obesity
Colorectal Neoplasms
Cholesterol
Education
Glucose
Case-Control Studies
Colon
Therapeutics
Logistic Models

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

Cite this

Aleksandrova, K., Boeing, H., Jenab, M., Bueno-de-Mesquita, H. B., Jansen, E., Van Duijnhoven, F. J. B., ... Pischon, T. (2011). Metabolic syndrome and risks of colon and rectal cancer: The european prospective investigation into cancer and nutrition study. Cancer Prevention Research, 4(11), 1873-1883. https://doi.org/10.1158/1940-6207.CAPR-11-0218

Metabolic syndrome and risks of colon and rectal cancer : The european prospective investigation into cancer and nutrition study. / Aleksandrova, Krasimira; Boeing, Heiner; Jenab, Mazda; Bueno-de-Mesquita, H. Bas; Jansen, Eugene; Van Duijnhoven, Fran̈zel J B; Fedirko, Veronika; Rinaldi, Sabina; Romieu, Isabelle; Riboli, Elio; Romaguera, Dora; Overvad, Kim; Østergaard, Jane Nautrup; Olsen, Anja; Tjnøneland, Anne; Boutron-Ruault, Marie Christine; Clavel-Chapelon, Franco̧ise; Morois, Sophie; Masala, Giovanna; Agnoli, Claudia; Panico, Salvatore; Tumino, Rosario; Vineis, Paolo; Kaaks, Rudolf; Lukanova, Annekatrin; Trichopoulou, Antonia; Naska, Androniki; Bamia, Christina; Peeters, Petra H.; Rodriǵuez, Laudina; Buckland, Genevieve; Sańchez, Mariá José; Dorronsoro, Miren; Huerta, Jose Mariá; Barricarte, Aurelio; Hallmans, Gor̈an; Palmqvist, Richard; Khaw, Kay Tee; Wareham, Nicholas; Allen, Naomi E.; Tsilidis, Konstantinos K.; Pischon, Tobias.

In: Cancer Prevention Research, Vol. 4, No. 11, 11.2011, p. 1873-1883.

Research output: Contribution to journalArticle

Aleksandrova, K, Boeing, H, Jenab, M, Bueno-de-Mesquita, HB, Jansen, E, Van Duijnhoven, FJB, Fedirko, V, Rinaldi, S, Romieu, I, Riboli, E, Romaguera, D, Overvad, K, Østergaard, JN, Olsen, A, Tjnøneland, A, Boutron-Ruault, MC, Clavel-Chapelon, F, Morois, S, Masala, G, Agnoli, C, Panico, S, Tumino, R, Vineis, P, Kaaks, R, Lukanova, A, Trichopoulou, A, Naska, A, Bamia, C, Peeters, PH, Rodriǵuez, L, Buckland, G, Sańchez, MJ, Dorronsoro, M, Huerta, JM, Barricarte, A, Hallmans, G, Palmqvist, R, Khaw, KT, Wareham, N, Allen, NE, Tsilidis, KK & Pischon, T 2011, 'Metabolic syndrome and risks of colon and rectal cancer: The european prospective investigation into cancer and nutrition study', Cancer Prevention Research, vol. 4, no. 11, pp. 1873-1883. https://doi.org/10.1158/1940-6207.CAPR-11-0218
Aleksandrova, Krasimira ; Boeing, Heiner ; Jenab, Mazda ; Bueno-de-Mesquita, H. Bas ; Jansen, Eugene ; Van Duijnhoven, Fran̈zel J B ; Fedirko, Veronika ; Rinaldi, Sabina ; Romieu, Isabelle ; Riboli, Elio ; Romaguera, Dora ; Overvad, Kim ; Østergaard, Jane Nautrup ; Olsen, Anja ; Tjnøneland, Anne ; Boutron-Ruault, Marie Christine ; Clavel-Chapelon, Franco̧ise ; Morois, Sophie ; Masala, Giovanna ; Agnoli, Claudia ; Panico, Salvatore ; Tumino, Rosario ; Vineis, Paolo ; Kaaks, Rudolf ; Lukanova, Annekatrin ; Trichopoulou, Antonia ; Naska, Androniki ; Bamia, Christina ; Peeters, Petra H. ; Rodriǵuez, Laudina ; Buckland, Genevieve ; Sańchez, Mariá José ; Dorronsoro, Miren ; Huerta, Jose Mariá ; Barricarte, Aurelio ; Hallmans, Gor̈an ; Palmqvist, Richard ; Khaw, Kay Tee ; Wareham, Nicholas ; Allen, Naomi E. ; Tsilidis, Konstantinos K. ; Pischon, Tobias. / Metabolic syndrome and risks of colon and rectal cancer : The european prospective investigation into cancer and nutrition study. In: Cancer Prevention Research. 2011 ; Vol. 4, No. 11. pp. 1873-1883.
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T1 - Metabolic syndrome and risks of colon and rectal cancer

T2 - The european prospective investigation into cancer and nutrition study

AU - Aleksandrova, Krasimira

AU - Boeing, Heiner

AU - Jenab, Mazda

AU - Bueno-de-Mesquita, H. Bas

AU - Jansen, Eugene

AU - Van Duijnhoven, Fran̈zel J B

AU - Fedirko, Veronika

AU - Rinaldi, Sabina

AU - Romieu, Isabelle

AU - Riboli, Elio

AU - Romaguera, Dora

AU - Overvad, Kim

AU - Østergaard, Jane Nautrup

AU - Olsen, Anja

AU - Tjnøneland, Anne

AU - Boutron-Ruault, Marie Christine

AU - Clavel-Chapelon, Franco̧ise

AU - Morois, Sophie

AU - Masala, Giovanna

AU - Agnoli, Claudia

AU - Panico, Salvatore

AU - Tumino, Rosario

AU - Vineis, Paolo

AU - Kaaks, Rudolf

AU - Lukanova, Annekatrin

AU - Trichopoulou, Antonia

AU - Naska, Androniki

AU - Bamia, Christina

AU - Peeters, Petra H.

AU - Rodriǵuez, Laudina

AU - Buckland, Genevieve

AU - Sańchez, Mariá José

AU - Dorronsoro, Miren

AU - Huerta, Jose Mariá

AU - Barricarte, Aurelio

AU - Hallmans, Gor̈an

AU - Palmqvist, Richard

AU - Khaw, Kay Tee

AU - Wareham, Nicholas

AU - Allen, Naomi E.

AU - Tsilidis, Konstantinos K.

AU - Pischon, Tobias

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N2 - Metabolic syndrome (MetS) is purportedly related to risk of developing colorectal cancer; however, the association of MetS, as defined according to recent international criteria, and colorectal cancer has not been yet evaluated. In particular, it remains unclear to what extent the MetS components individually account for such an association. We addressed these issues in a nested case-control study that included 1,093 incident cases matched (1:1) to controls by using incidence density sampling. Conditional logistic regression was used to estimate relative risks (RR) and 95% CIs. MetS was defined according to the criteria of the National Cholesterol Education Program/Adult Treatment Panel III (NCEP/ATPIII), the International Diabetes Federation (IDF), and the 2009 harmonized definition. Among individual components, abdominal obesity (RR = 1.51; 95% CI: 1.16-1.96) was associated with colon cancer, whereas abnormal glucose metabolism was associated with both colon (RR = 2.05; 95% CI: 1.57-2.68) and rectal cancer (RR = 2.07; 95% CI: 1.45-2.96). MetS, as defined by each of the definitions, was similarly associated with colon cancer (e.g., RR = 1.91; 95% CI: 1.47-2.42 for MetS by NCEP/ATPIII), whereas MetS by NCEP/ATPIII, but not IDF or harmonized definition, was associated with rectal cancer (RR = 1.45; 95% CI: 1.02-2.06). Overall, these associations were stronger in women than in men. However, the association between MetS and colorectal cancer was accounted for by abdominal obesity and abnormal glucose metabolism such that MetS did not provide risk information beyond these components (likelihood ratio test P = 0.10 for MetS by NCEP/ ATPIII). These data suggest that simple assessment of abnormal glucose metabolism and/or abdominal obesity to identify individuals at colorectal cancer risk may have higher clinical utility than applying more complex MetS definitions.

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