Metabolic syndrome and the risk of vascular dementia: The Italian Longitudinal Study on Ageing

Vincenzo Solfrizzi, Emanuele Scafato, Cristiano Capurso, Alessia D'Introno, Anna Maria Colacicco, Vincenza Frisardi, Gianluigi Vendemiale, Marzia Baldereschi, Gaetano Crepaldi, Antonio Di Carlo, Lucia Galluzzo, Claudia Gandin, Domenico Inzitari, Stefania Maggi, Antonio Capurso, Francesco Panza

Research output: Contribution to journalArticlepeer-review

Abstract

Objective The authors investigated the relationship of metabolic syndrome (MetS) and its individual components with incident dementia in a prospective population-based study with a 3.5-year follow-up. Methods A total of 2097 participants from a sample of 5632 subjects (65e84 years old) from the Italian Longitudinal Study on Ageing were evaluated. MetS was defined according to the Third Adults Treatment Panel of the National Cholesterol Education Program criteria. Dementia, Alzheimer disease (AD) and vascular dementia (VaD) were classified using current published criteria. Results MetS subjects (N918) compared with those without MetS (N1179) had an increased risk for VaD (1.63% vs 0.85%, adjusted hazard ratio (HR) 3.71, 95% CI 1.40 to 9.83). After excluding 338 subjects with baseline undernutrition, MetS subjects compared with those without MetS had an elevated risk of VaD (adjusted HR, 3.82; 95% CI 1.32 to 11.06). Moreover, those with MetS and high inflammation had a still further higher risk of VaD (multivariate adjusted HR, 9.55; 95% CI 1.17 to 78.17) compared with those without MetS and high inflammation. On the other hand, those with MetS and low inflammation compared with those without MetS and low inflammation did not exhibit a significant increased risk of VaD (adjusted HR, 3.31, 95% CI 0.91 to 12.14). Finally, a synergistic MetS effect versus its individual component effects was verified on the risk of VaD. Conclusion In our population, MetS subjects had an elevated risk of VaD that increased after excluding patients with baseline undernutrition and selecting MetS subjects with high inflammation.

Original languageEnglish
Pages (from-to)433-440
Number of pages8
JournalJournal of Neurology, Neurosurgery and Psychiatry
Volume81
Issue number4
DOIs
Publication statusPublished - Apr 2010

ASJC Scopus subject areas

  • Clinical Neurology
  • Psychiatry and Mental health
  • Surgery

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