TY - JOUR
T1 - Metabolic syndrome correlates with peri-urethral fibrosis secondary to chronic prostate inflammation
T2 - Evidence of a link in a cohort of patients undergoing radical prostatectomy
AU - Cantiello, Francesco
AU - Cicione, Antonio
AU - Salonia, Andrea
AU - Autorino, Riccardo
AU - Ucciero, Giuseppe
AU - Tucci, Luigi
AU - Briganti, Alberto
AU - Damiano, Rocco
PY - 2014/3
Y1 - 2014/3
N2 - Objectives: To investigate the pathological relationship between metabolic syndrome and peri-urethral fibrosis status secondary to chronic prostate inflammation. Methods: Peri-urethral prostate tissue from 80 consecutive patients who underwent retropubic radical prostatectomy for prostate cancer was analyzed. Patients were divided in two groups according to whether or not they had a diagnosis of metabolic syndrome. A 16-peri-urethral core bench biopsy was carried out on each radical prostatectomy specimen to evaluate the extent of peri-urethral inflammatory infiltrate, and collagen and elastin amount. Spearman's correlation analysis was used to test the association between variables. Furthermore, the data were used to define a bivariate logistic regression model in which the presence (>50% collagen amount for each patients) or absence (≤50% collagen amount) of fibrosis was analyzed after adjusting for clinical and pathological variables. Results: A significant difference was found between the two groups in terms of International Prostatic Symptoms Score (P
AB - Objectives: To investigate the pathological relationship between metabolic syndrome and peri-urethral fibrosis status secondary to chronic prostate inflammation. Methods: Peri-urethral prostate tissue from 80 consecutive patients who underwent retropubic radical prostatectomy for prostate cancer was analyzed. Patients were divided in two groups according to whether or not they had a diagnosis of metabolic syndrome. A 16-peri-urethral core bench biopsy was carried out on each radical prostatectomy specimen to evaluate the extent of peri-urethral inflammatory infiltrate, and collagen and elastin amount. Spearman's correlation analysis was used to test the association between variables. Furthermore, the data were used to define a bivariate logistic regression model in which the presence (>50% collagen amount for each patients) or absence (≤50% collagen amount) of fibrosis was analyzed after adjusting for clinical and pathological variables. Results: A significant difference was found between the two groups in terms of International Prostatic Symptoms Score (P
KW - Lower urinary tract symptoms
KW - Metabolic syndrome
KW - Peri-urethral fibrosis
KW - Prostate inflammation
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U2 - 10.1111/iju.12233
DO - 10.1111/iju.12233
M3 - Article
C2 - 23909794
AN - SCOPUS:84896737568
VL - 21
SP - 264
EP - 269
JO - International Journal of Urology
JF - International Journal of Urology
SN - 0919-8172
IS - 3
ER -