Metabolic syndrome in adult patients with Prader-Willi syndrome

G. Grugni, A. Crinò, G. Bedogni, M. Cappa, A. Sartorio, A. Corrias, S. Di Candia, L. Gargantini, L. Iughetti, C. Pagano, L. Ragusa, A. Salvatoni, S. Spera, R. Vettor, G. Chiumello, P. Brambilla

Research output: Contribution to journalArticle

Abstract

Background and aims: Prader-Willi syndrome (PWS), the most common genetic cause of obesity, is characterized by elevated morbility and mortality in all ages. In this context, non-obese PWS children showed low frequency of metabolic syndrome (MetS), while a comparable prevalence was observed in obese PWS and obese controls. Aim of this study was to estimate the occurrence of MetS and its components in a large group of PWS adults, according to obesity status. Methods and results: A cross-sectional study was performed in 108 PWS aged 18.0-43.2 years (87 obese and 21 non-obese) and in 85 controls with nonsyndromic obesity matched for age, gender, and BMI with obese PWS.Non-obese PWS showed lower waist circumference, insulin, HOMA-index, triglycerides, diastolic blood pressure, and higher HDL-C than both obese PWS and obese controls (p

Original languageEnglish
Pages (from-to)1134-1140
Number of pages7
JournalNutrition, Metabolism and Cardiovascular Diseases
Volume23
Issue number11
DOIs
Publication statusPublished - 2013

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Keywords

  • BMI
  • BP
  • DELETED
  • HDL-C
  • HOMA-index
  • Hypertension
  • Insulin
  • Lipids
  • Metabolic syndrome
  • MetS
  • Obesity
  • Prader-Willi syndrome
  • PWS
  • T2DM
  • UPD15
  • WC

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Nutrition and Dietetics
  • Endocrinology, Diabetes and Metabolism
  • Cardiology and Cardiovascular Medicine

Cite this

Grugni, G., Crinò, A., Bedogni, G., Cappa, M., Sartorio, A., Corrias, A., Di Candia, S., Gargantini, L., Iughetti, L., Pagano, C., Ragusa, L., Salvatoni, A., Spera, S., Vettor, R., Chiumello, G., & Brambilla, P. (2013). Metabolic syndrome in adult patients with Prader-Willi syndrome. Nutrition, Metabolism and Cardiovascular Diseases, 23(11), 1134-1140. https://doi.org/10.1016/j.numecd.2012.11.006