Abstract
Background and aims: Prader-Willi syndrome (PWS), the most common genetic cause of obesity, is characterized by elevated morbility and mortality in all ages. In this context, non-obese PWS children showed low frequency of metabolic syndrome (MetS), while a comparable prevalence was observed in obese PWS and obese controls. Aim of this study was to estimate the occurrence of MetS and its components in a large group of PWS adults, according to obesity status. Methods and results: A cross-sectional study was performed in 108 PWS aged 18.0-43.2 years (87 obese and 21 non-obese) and in 85 controls with nonsyndromic obesity matched for age, gender, and BMI with obese PWS.Non-obese PWS showed lower waist circumference, insulin, HOMA-index, triglycerides, diastolic blood pressure, and higher HDL-C than both obese PWS and obese controls (p
Original language | English |
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Pages (from-to) | 1134-1140 |
Number of pages | 7 |
Journal | Nutrition, Metabolism and Cardiovascular Diseases |
Volume | 23 |
Issue number | 11 |
DOIs | |
Publication status | Published - 2013 |
Keywords
- BMI
- BP
- DELETED
- HDL-C
- HOMA-index
- Hypertension
- Insulin
- Lipids
- Metabolic syndrome
- MetS
- Obesity
- Prader-Willi syndrome
- PWS
- T2DM
- UPD15
- WC
ASJC Scopus subject areas
- Medicine (miscellaneous)
- Nutrition and Dietetics
- Endocrinology, Diabetes and Metabolism
- Cardiology and Cardiovascular Medicine