Metabolic syndrome in adult patients with Prader-Willi syndrome

G. Grugni, A. Crinò, G. Bedogni, M. Cappa, A. Sartorio, A. Corrias, S. Di Candia, L. Gargantini, L. Iughetti, C. Pagano, L. Ragusa, A. Salvatoni, S. Spera, R. Vettor, G. Chiumello, P. Brambilla

Research output: Contribution to journalArticle

20 Citations (Scopus)

Abstract

Background and aims: Prader-Willi syndrome (PWS), the most common genetic cause of obesity, is characterized by elevated morbility and mortality in all ages. In this context, non-obese PWS children showed low frequency of metabolic syndrome (MetS), while a comparable prevalence was observed in obese PWS and obese controls. Aim of this study was to estimate the occurrence of MetS and its components in a large group of PWS adults, according to obesity status. Methods and results: A cross-sectional study was performed in 108 PWS aged 18.0-43.2 years (87 obese and 21 non-obese) and in 85 controls with nonsyndromic obesity matched for age, gender, and BMI with obese PWS.Non-obese PWS showed lower waist circumference, insulin, HOMA-index, triglycerides, diastolic blood pressure, and higher HDL-C than both obese PWS and obese controls (p

Original languageEnglish
Pages (from-to)1134-1140
Number of pages7
JournalNutrition, Metabolism and Cardiovascular Diseases
Volume23
Issue number11
DOIs
Publication statusPublished - 2013

Fingerprint

Prader-Willi Syndrome
Obesity
Blood Pressure
Waist Circumference
Triglycerides
Cross-Sectional Studies
Insulin
Mortality

Keywords

  • BMI
  • BP
  • DELETED
  • HDL-C
  • HOMA-index
  • Hypertension
  • Insulin
  • Lipids
  • Metabolic syndrome
  • MetS
  • Obesity
  • Prader-Willi syndrome
  • PWS
  • T2DM
  • UPD15
  • WC

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Nutrition and Dietetics
  • Endocrinology, Diabetes and Metabolism
  • Cardiology and Cardiovascular Medicine

Cite this

Metabolic syndrome in adult patients with Prader-Willi syndrome. / Grugni, G.; Crinò, A.; Bedogni, G.; Cappa, M.; Sartorio, A.; Corrias, A.; Di Candia, S.; Gargantini, L.; Iughetti, L.; Pagano, C.; Ragusa, L.; Salvatoni, A.; Spera, S.; Vettor, R.; Chiumello, G.; Brambilla, P.

In: Nutrition, Metabolism and Cardiovascular Diseases, Vol. 23, No. 11, 2013, p. 1134-1140.

Research output: Contribution to journalArticle

Grugni, G, Crinò, A, Bedogni, G, Cappa, M, Sartorio, A, Corrias, A, Di Candia, S, Gargantini, L, Iughetti, L, Pagano, C, Ragusa, L, Salvatoni, A, Spera, S, Vettor, R, Chiumello, G & Brambilla, P 2013, 'Metabolic syndrome in adult patients with Prader-Willi syndrome', Nutrition, Metabolism and Cardiovascular Diseases, vol. 23, no. 11, pp. 1134-1140. https://doi.org/10.1016/j.numecd.2012.11.006
Grugni, G. ; Crinò, A. ; Bedogni, G. ; Cappa, M. ; Sartorio, A. ; Corrias, A. ; Di Candia, S. ; Gargantini, L. ; Iughetti, L. ; Pagano, C. ; Ragusa, L. ; Salvatoni, A. ; Spera, S. ; Vettor, R. ; Chiumello, G. ; Brambilla, P. / Metabolic syndrome in adult patients with Prader-Willi syndrome. In: Nutrition, Metabolism and Cardiovascular Diseases. 2013 ; Vol. 23, No. 11. pp. 1134-1140.
@article{f9fa793ff2cd4a77a23a041fd59f193d,
title = "Metabolic syndrome in adult patients with Prader-Willi syndrome",
abstract = "Background and aims: Prader-Willi syndrome (PWS), the most common genetic cause of obesity, is characterized by elevated morbility and mortality in all ages. In this context, non-obese PWS children showed low frequency of metabolic syndrome (MetS), while a comparable prevalence was observed in obese PWS and obese controls. Aim of this study was to estimate the occurrence of MetS and its components in a large group of PWS adults, according to obesity status. Methods and results: A cross-sectional study was performed in 108 PWS aged 18.0-43.2 years (87 obese and 21 non-obese) and in 85 controls with nonsyndromic obesity matched for age, gender, and BMI with obese PWS.Non-obese PWS showed lower waist circumference, insulin, HOMA-index, triglycerides, diastolic blood pressure, and higher HDL-C than both obese PWS and obese controls (p",
keywords = "BMI, BP, DELETED, HDL-C, HOMA-index, Hypertension, Insulin, Lipids, Metabolic syndrome, MetS, Obesity, Prader-Willi syndrome, PWS, T2DM, UPD15, WC",
author = "G. Grugni and A. Crin{\`o} and G. Bedogni and M. Cappa and A. Sartorio and A. Corrias and {Di Candia}, S. and L. Gargantini and L. Iughetti and C. Pagano and L. Ragusa and A. Salvatoni and S. Spera and R. Vettor and G. Chiumello and P. Brambilla",
year = "2013",
doi = "10.1016/j.numecd.2012.11.006",
language = "English",
volume = "23",
pages = "1134--1140",
journal = "Nutrition, Metabolism and Cardiovascular Diseases",
issn = "0939-4753",
publisher = "Elsevier B.V.",
number = "11",

}

TY - JOUR

T1 - Metabolic syndrome in adult patients with Prader-Willi syndrome

AU - Grugni, G.

AU - Crinò, A.

AU - Bedogni, G.

AU - Cappa, M.

AU - Sartorio, A.

AU - Corrias, A.

AU - Di Candia, S.

AU - Gargantini, L.

AU - Iughetti, L.

AU - Pagano, C.

AU - Ragusa, L.

AU - Salvatoni, A.

AU - Spera, S.

AU - Vettor, R.

AU - Chiumello, G.

AU - Brambilla, P.

PY - 2013

Y1 - 2013

N2 - Background and aims: Prader-Willi syndrome (PWS), the most common genetic cause of obesity, is characterized by elevated morbility and mortality in all ages. In this context, non-obese PWS children showed low frequency of metabolic syndrome (MetS), while a comparable prevalence was observed in obese PWS and obese controls. Aim of this study was to estimate the occurrence of MetS and its components in a large group of PWS adults, according to obesity status. Methods and results: A cross-sectional study was performed in 108 PWS aged 18.0-43.2 years (87 obese and 21 non-obese) and in 85 controls with nonsyndromic obesity matched for age, gender, and BMI with obese PWS.Non-obese PWS showed lower waist circumference, insulin, HOMA-index, triglycerides, diastolic blood pressure, and higher HDL-C than both obese PWS and obese controls (p

AB - Background and aims: Prader-Willi syndrome (PWS), the most common genetic cause of obesity, is characterized by elevated morbility and mortality in all ages. In this context, non-obese PWS children showed low frequency of metabolic syndrome (MetS), while a comparable prevalence was observed in obese PWS and obese controls. Aim of this study was to estimate the occurrence of MetS and its components in a large group of PWS adults, according to obesity status. Methods and results: A cross-sectional study was performed in 108 PWS aged 18.0-43.2 years (87 obese and 21 non-obese) and in 85 controls with nonsyndromic obesity matched for age, gender, and BMI with obese PWS.Non-obese PWS showed lower waist circumference, insulin, HOMA-index, triglycerides, diastolic blood pressure, and higher HDL-C than both obese PWS and obese controls (p

KW - BMI

KW - BP

KW - DELETED

KW - HDL-C

KW - HOMA-index

KW - Hypertension

KW - Insulin

KW - Lipids

KW - Metabolic syndrome

KW - MetS

KW - Obesity

KW - Prader-Willi syndrome

KW - PWS

KW - T2DM

KW - UPD15

KW - WC

UR - http://www.scopus.com/inward/record.url?scp=84887610381&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84887610381&partnerID=8YFLogxK

U2 - 10.1016/j.numecd.2012.11.006

DO - 10.1016/j.numecd.2012.11.006

M3 - Article

C2 - 23220075

AN - SCOPUS:84887610381

VL - 23

SP - 1134

EP - 1140

JO - Nutrition, Metabolism and Cardiovascular Diseases

JF - Nutrition, Metabolism and Cardiovascular Diseases

SN - 0939-4753

IS - 11

ER -