Metabolic syndrome in adult patients with Prader-Willi syndrome

G. Grugni; A. Crinò; G. Bedogni; M. Cappa; A. Sartorio; A. Corrias; S. Di Candia; L. Gargantini; L. Iughetti; C. Pagano; L. Ragusa; A. Salvatoni; S. Spera; R. Vettor; G. Chiumello; P. Brambilla

doi:10.1016/j.numecd.2012.11.006

Metabolic syndrome in adult patients with Prader-Willi syndrome

G. Grugni, A. Crinò, G. Bedogni, M. Cappa, A. Sartorio, A. Corrias, S. Di Candia, L. Gargantini, L. Iughetti, C. Pagano, L. Ragusa, A. Salvatoni, S. Spera, R. Vettor, G. Chiumello, P. Brambilla

Research output: Contribution to journal › Article

Abstract

Background and aims: Prader-Willi syndrome (PWS), the most common genetic cause of obesity, is characterized by elevated morbility and mortality in all ages. In this context, non-obese PWS children showed low frequency of metabolic syndrome (MetS), while a comparable prevalence was observed in obese PWS and obese controls. Aim of this study was to estimate the occurrence of MetS and its components in a large group of PWS adults, according to obesity status. Methods and results: A cross-sectional study was performed in 108 PWS aged 18.0-43.2 years (87 obese and 21 non-obese) and in 85 controls with nonsyndromic obesity matched for age, gender, and BMI with obese PWS.Non-obese PWS showed lower waist circumference, insulin, HOMA-index, triglycerides, diastolic blood pressure, and higher HDL-C than both obese PWS and obese controls (p

Original language	English
Pages (from-to)	1134-1140
Number of pages	7
Journal	Nutrition, Metabolism and Cardiovascular Diseases
Volume	23
Issue number	11
DOIs	https://doi.org/10.1016/j.numecd.2012.11.006
Publication status	Published - 2013

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Keywords

BMI
BP
DELETED
HDL-C
HOMA-index
Hypertension
Insulin
Lipids
Metabolic syndrome
MetS
Obesity
Prader-Willi syndrome
PWS
T2DM
UPD15
WC

ASJC Scopus subject areas

Medicine (miscellaneous)
Nutrition and Dietetics
Endocrinology, Diabetes and Metabolism
Cardiology and Cardiovascular Medicine

Cite this

Grugni, G., Crinò, A., Bedogni, G., Cappa, M., Sartorio, A., Corrias, A., Di Candia, S., Gargantini, L., Iughetti, L., Pagano, C., Ragusa, L., Salvatoni, A., Spera, S., Vettor, R., Chiumello, G., & Brambilla, P. (2013). Metabolic syndrome in adult patients with Prader-Willi syndrome. Nutrition, Metabolism and Cardiovascular Diseases, 23(11), 1134-1140. https://doi.org/10.1016/j.numecd.2012.11.006

Metabolic syndrome in adult patients with Prader-Willi syndrome. / Grugni, G.; Crinò, A.; Bedogni, G.; Cappa, M.; Sartorio, A.; Corrias, A.; Di Candia, S.; Gargantini, L.; Iughetti, L.; Pagano, C.; Ragusa, L.; Salvatoni, A.; Spera, S.; Vettor, R.; Chiumello, G.; Brambilla, P.

In: Nutrition, Metabolism and Cardiovascular Diseases, Vol. 23, No. 11, 2013, p. 1134-1140.

Research output: Contribution to journal › Article

Grugni, G , Crinò, A, Bedogni, G, Cappa, M , Sartorio, A, Corrias, A, Di Candia, S, Gargantini, L, Iughetti, L, Pagano, C, Ragusa, L, Salvatoni, A, Spera, S, Vettor, R, Chiumello, G & Brambilla, P 2013, 'Metabolic syndrome in adult patients with Prader-Willi syndrome', Nutrition, Metabolism and Cardiovascular Diseases, vol. 23, no. 11, pp. 1134-1140. https://doi.org/10.1016/j.numecd.2012.11.006

Grugni, G. ; Crinò, A. ; Bedogni, G. ; Cappa, M. ; Sartorio, A. ; Corrias, A. ; Di Candia, S. ; Gargantini, L. ; Iughetti, L. ; Pagano, C. ; Ragusa, L. ; Salvatoni, A. ; Spera, S. ; Vettor, R. ; Chiumello, G. ; Brambilla, P. / Metabolic syndrome in adult patients with Prader-Willi syndrome. In: Nutrition, Metabolism and Cardiovascular Diseases. 2013 ; Vol. 23, No. 11. pp. 1134-1140.

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AU - Corrias, A.

AU - Di Candia, S.

AU - Gargantini, L.

AU - Iughetti, L.

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AU - Ragusa, L.

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AU - Chiumello, G.

AU - Brambilla, P.

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10.1016/j.numecd.2012.11.006