Abstract
Background and aims: Prader-Willi syndrome (PWS), the most common genetic cause of obesity, is characterized by elevated morbility and mortality in all ages. In this context, non-obese PWS children showed low frequency of metabolic syndrome (MetS), while a comparable prevalence was observed in obese PWS and obese controls. Aim of this study was to estimate the occurrence of MetS and its components in a large group of PWS adults, according to obesity status. Methods and results: A cross-sectional study was performed in 108 PWS aged 18.0-43.2 years (87 obese and 21 non-obese) and in 85 controls with nonsyndromic obesity matched for age, gender, and BMI with obese PWS.Non-obese PWS showed lower waist circumference, insulin, HOMA-index, triglycerides, diastolic blood pressure, and higher HDL-C than both obese PWS and obese controls (p
| Original language | English |
|---|---|
| Pages (from-to) | 1134-1140 |
| Number of pages | 7 |
| Journal | Nutrition, Metabolism and Cardiovascular Diseases |
| Volume | 23 |
| Issue number | 11 |
| DOIs | |
| Publication status | Published - 2013 |
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Keywords
- BMI
- BP
- DELETED
- HDL-C
- HOMA-index
- Hypertension
- Insulin
- Lipids
- Metabolic syndrome
- MetS
- Obesity
- Prader-Willi syndrome
- PWS
- T2DM
- UPD15
- WC
ASJC Scopus subject areas
- Medicine (miscellaneous)
- Nutrition and Dietetics
- Endocrinology, Diabetes and Metabolism
- Cardiology and Cardiovascular Medicine
Cite this
Metabolic syndrome in adult patients with Prader-Willi syndrome. / Grugni, G.; Crinò, A.; Bedogni, G.; Cappa, M.; Sartorio, A.; Corrias, A.; Di Candia, S.; Gargantini, L.; Iughetti, L.; Pagano, C.; Ragusa, L.; Salvatoni, A.; Spera, S.; Vettor, R.; Chiumello, G.; Brambilla, P.
In: Nutrition, Metabolism and Cardiovascular Diseases, Vol. 23, No. 11, 2013, p. 1134-1140.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Metabolic syndrome in adult patients with Prader-Willi syndrome
AU - Grugni, G.
AU - Crinò, A.
AU - Bedogni, G.
AU - Cappa, M.
AU - Sartorio, A.
AU - Corrias, A.
AU - Di Candia, S.
AU - Gargantini, L.
AU - Iughetti, L.
AU - Pagano, C.
AU - Ragusa, L.
AU - Salvatoni, A.
AU - Spera, S.
AU - Vettor, R.
AU - Chiumello, G.
AU - Brambilla, P.
PY - 2013
Y1 - 2013
N2 - Background and aims: Prader-Willi syndrome (PWS), the most common genetic cause of obesity, is characterized by elevated morbility and mortality in all ages. In this context, non-obese PWS children showed low frequency of metabolic syndrome (MetS), while a comparable prevalence was observed in obese PWS and obese controls. Aim of this study was to estimate the occurrence of MetS and its components in a large group of PWS adults, according to obesity status. Methods and results: A cross-sectional study was performed in 108 PWS aged 18.0-43.2 years (87 obese and 21 non-obese) and in 85 controls with nonsyndromic obesity matched for age, gender, and BMI with obese PWS.Non-obese PWS showed lower waist circumference, insulin, HOMA-index, triglycerides, diastolic blood pressure, and higher HDL-C than both obese PWS and obese controls (p
AB - Background and aims: Prader-Willi syndrome (PWS), the most common genetic cause of obesity, is characterized by elevated morbility and mortality in all ages. In this context, non-obese PWS children showed low frequency of metabolic syndrome (MetS), while a comparable prevalence was observed in obese PWS and obese controls. Aim of this study was to estimate the occurrence of MetS and its components in a large group of PWS adults, according to obesity status. Methods and results: A cross-sectional study was performed in 108 PWS aged 18.0-43.2 years (87 obese and 21 non-obese) and in 85 controls with nonsyndromic obesity matched for age, gender, and BMI with obese PWS.Non-obese PWS showed lower waist circumference, insulin, HOMA-index, triglycerides, diastolic blood pressure, and higher HDL-C than both obese PWS and obese controls (p
KW - BMI
KW - BP
KW - DELETED
KW - HDL-C
KW - HOMA-index
KW - Hypertension
KW - Insulin
KW - Lipids
KW - Metabolic syndrome
KW - MetS
KW - Obesity
KW - Prader-Willi syndrome
KW - PWS
KW - T2DM
KW - UPD15
KW - WC
UR - http://www.scopus.com/inward/record.url?scp=84887610381&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84887610381&partnerID=8YFLogxK
U2 - 10.1016/j.numecd.2012.11.006
DO - 10.1016/j.numecd.2012.11.006
M3 - Article
C2 - 23220075
AN - SCOPUS:84887610381
VL - 23
SP - 1134
EP - 1140
JO - Nutrition, Metabolism and Cardiovascular Diseases
JF - Nutrition, Metabolism and Cardiovascular Diseases
SN - 0939-4753
IS - 11
ER -