Metabolic syndrome in childhood leukemia survivors: a meta-analysis

Maria Felicia Faienza, Maurizio Delvecchio, Paola Giordano, Luciano Cavallo, Maria Grano, Giacomina Brunetti, Annamaria Ventura

Research output: Contribution to journalArticle


A significant number of long-term complications have been described in childhood leukemia survivors. In particular, these patients may present features of metabolic syndrome (MetS), and therefore increased risk for cardiovascular diseases. The aim of this meta-analysis is to evaluate the prevalence and the risk of MetS in survivors of childhood leukemia. Two authors independently performed a systematic literature search in PubMed and EMBASE to March 2014, reviewed and selected articles, based on pre-determined selection criteria. Twelve articles, comprising 2,337 participants (1,462 cases and 875 controls), were included in the meta-analysis. Only three of them were case–control studies eligible for the meta-analysis. The childhood leukemia survivors showed an increased risk of MetS as compared to healthy controls (OR = 4.36; 95 % CI 1.19–16.22). The risk was significantly increased only in patients treated with chemotherapy and radiotherapy (OR = 7.79; 95 % CI 1.27–47.77), and not in patients treated with only chemotherapy (OR = 2.35; 95 % CI 0.40–13.78). Childhood leukemia survivors, in particular if treated also with radiotherapy, are prone to develop MetS more than healthy controls. Monitoring of MetS components in these patients is necessary to avoid cardiovascular consequences later in life.

Original languageEnglish
Pages (from-to)353-360
Number of pages8
Issue number2
Publication statusPublished - Jun 28 2015


  • Chemotherapy
  • Childhood leukemia survivors
  • Meta-analysis
  • Metabolic syndrome
  • Radiotherapy

ASJC Scopus subject areas

  • Endocrinology
  • Endocrinology, Diabetes and Metabolism

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  • Cite this

    Faienza, M. F., Delvecchio, M., Giordano, P., Cavallo, L., Grano, M., Brunetti, G., & Ventura, A. (2015). Metabolic syndrome in childhood leukemia survivors: a meta-analysis. Endocrine, 49(2), 353-360.