TY - JOUR
T1 - Metabolic Syndrome in Heart Failure
T2 - Friend or Foe?
AU - Arcopinto, Michele
AU - Schiavo, Alessandra
AU - Salzano, Andrea
AU - Bossone, Eduardo
AU - D'Assante, Roberta
AU - Marsico, Fabio
AU - Demelo-Rodriguez, Pablo
AU - Baliga, Ragavendra R.
AU - Cittadini, Antonio
AU - Marra, Alberto M.
PY - 2019/7
Y1 - 2019/7
N2 - The interplay between metabolic syndrome (MetS)and heart failure (HF)is intricate. Population studies show that MetS confers an increased risk to develop HF and this effect is mediated by insulin resistance (IR). However, obesity, a key component in MetS and common partner of IR, is protective in patients with established HF, although IR confers an increased risk of dying by HF. Such phenomenon, known as “obesity paradox,” accounts for the complexity of the HF-MetS relationship. Because IR impacts more on outcomes than MetS itself, the former may be considered the actual target for MetS in HF patients.
AB - The interplay between metabolic syndrome (MetS)and heart failure (HF)is intricate. Population studies show that MetS confers an increased risk to develop HF and this effect is mediated by insulin resistance (IR). However, obesity, a key component in MetS and common partner of IR, is protective in patients with established HF, although IR confers an increased risk of dying by HF. Such phenomenon, known as “obesity paradox,” accounts for the complexity of the HF-MetS relationship. Because IR impacts more on outcomes than MetS itself, the former may be considered the actual target for MetS in HF patients.
KW - Heart failure
KW - Insulin resistance
KW - Metabolic syndrome
KW - Prognosis
KW - Risk stratification
UR - http://www.scopus.com/inward/record.url?scp=85063894992&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85063894992&partnerID=8YFLogxK
U2 - 10.1016/j.hfc.2019.02.004
DO - 10.1016/j.hfc.2019.02.004
M3 - Review article
C2 - 31079693
AN - SCOPUS:85063894992
VL - 15
SP - 349
EP - 358
JO - Heart Failure Clinics
JF - Heart Failure Clinics
SN - 1551-7136
IS - 3
ER -