Metabolic Syndrome in Heart Failure: Friend or Foe?

Michele Arcopinto; Alessandra Schiavo; Andrea Salzano; Eduardo Bossone; Roberta D'Assante; Fabio Marsico; Pablo Demelo-Rodriguez; Ragavendra R. Baliga; Antonio Cittadini; Alberto M. Marra

doi:10.1016/j.hfc.2019.02.004

Metabolic Syndrome in Heart Failure: Friend or Foe?

Michele Arcopinto, Alessandra Schiavo, Andrea Salzano, Eduardo Bossone, Roberta D'Assante, Fabio Marsico, Pablo Demelo-Rodriguez, Ragavendra R. Baliga, Antonio Cittadini, Alberto M. Marra

Research output: Contribution to journal › Review article › peer-review

Abstract

The interplay between metabolic syndrome (MetS)and heart failure (HF)is intricate. Population studies show that MetS confers an increased risk to develop HF and this effect is mediated by insulin resistance (IR). However, obesity, a key component in MetS and common partner of IR, is protective in patients with established HF, although IR confers an increased risk of dying by HF. Such phenomenon, known as “obesity paradox,” accounts for the complexity of the HF-MetS relationship. Because IR impacts more on outcomes than MetS itself, the former may be considered the actual target for MetS in HF patients.

Original language	English
Pages (from-to)	349-358
Number of pages	10
Journal	Heart Failure Clinics
Volume	15
Issue number	3
DOIs	https://doi.org/10.1016/j.hfc.2019.02.004
Publication status	Published - Jul 2019

Keywords

Heart failure
Insulin resistance
Metabolic syndrome
Prognosis
Risk stratification

ASJC Scopus subject areas

Cardiology and Cardiovascular Medicine

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10.1016/j.hfc.2019.02.004

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Metabolic Syndrome in Heart Failure : Friend or Foe? / Arcopinto, Michele; Schiavo, Alessandra; Salzano, Andrea; Bossone, Eduardo; D'Assante, Roberta; Marsico, Fabio; Demelo-Rodriguez, Pablo; Baliga, Ragavendra R.; Cittadini, Antonio; Marra, Alberto M.

In: Heart Failure Clinics, Vol. 15, No. 3, 07.2019, p. 349-358.

Research output: Contribution to journal › Review article › peer-review

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title = "Metabolic Syndrome in Heart Failure: Friend or Foe?",

abstract = "The interplay between metabolic syndrome (MetS)and heart failure (HF)is intricate. Population studies show that MetS confers an increased risk to develop HF and this effect is mediated by insulin resistance (IR). However, obesity, a key component in MetS and common partner of IR, is protective in patients with established HF, although IR confers an increased risk of dying by HF. Such phenomenon, known as “obesity paradox,” accounts for the complexity of the HF-MetS relationship. Because IR impacts more on outcomes than MetS itself, the former may be considered the actual target for MetS in HF patients.",

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AU - Arcopinto, Michele

AU - Schiavo, Alessandra

AU - Salzano, Andrea

AU - Bossone, Eduardo

AU - D'Assante, Roberta

AU - Marsico, Fabio

AU - Demelo-Rodriguez, Pablo

AU - Baliga, Ragavendra R.

AU - Cittadini, Antonio

AU - Marra, Alberto M.

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KW - Insulin resistance

KW - Metabolic syndrome

KW - Prognosis

KW - Risk stratification

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Metabolic Syndrome in Heart Failure: Friend or Foe?

Abstract

Keywords

ASJC Scopus subject areas

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