Metabolic syndrome in human immunodeficiency virus-positive subjects: Prevalence, phenotype, and related alterations in arterial structure and function

Alessandro Maloberti, Christina Giannattasio, Dario Dozio, Mauro Betelli, Paulo Villa, Stefano Nava, Francesca Cesana, Rita Facchetti, Luca Giupponi, Francesco Castagna, Francesca Sabbatini, Alessandra Bandera, Andre Gori, Guido Grassi, Giuseppe Mancia

Research output: Contribution to journalArticlepeer-review

Abstract

Background: Human immunodeficiency virus (HIV) infection itself and highly active antiretroviral treatment (HAART) have been proposed to be associated with a higher prevalence of metabolic syndrome, but, to date, prevalence and phenotype of metabolic syndrome among HIV subjects and the related structural and functional vascular alterations are not conclusively defined. Methods: We analyzed the data of 108 HIV-infected subjects without known cardiovascular risk factors: 72 were on HAART (group A, age 46.5±7.5 years, clinical blood pressure 125.7/74.9±11.6/7.8 mmHg) and there 36 in a naïve group (group B, age 40.7±7.9 years, blood pressure 126/75.8±9.8/7.7 mmHg). A total of 224 healthy subjects served as controls (group C, age 44.9±6.9 years, blood pressure 123.7/75.7±9.8/7.1 mmHg). Arterial stiffness was measured by aorto-femoral pulse wave velocity (PWV, sfigmocor), and carotid intima media thickness (IMT) was measured by a semiautomatic echotracking system (Esaote-WTS). Results: Metabolic syndrome was more frequent in HIV-positive subjects than in controls (19.4%, 13.8%, 4.5% for groups A, B, and C; P

Original languageEnglish
Pages (from-to)403-411
Number of pages9
JournalMetabolic Syndrome and Related Disorders
Volume11
Issue number6
DOIs
Publication statusPublished - Dec 1 2013

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Internal Medicine

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