Metabolic syndrome in the Pressioni Arteriose Monitorate E Loro Associazioni (PAMELA) study: Daily life blood pressure, cardiac damage, and prognosis

Giuseppe Mancia, Michele Bombelli, Giovanni Corrao, Rita Facchetti, Fabiana Madotto, Cristina Giannattasio, Fosca Quarti Trevano, Guido Grassi, Alberto Zanchetti, Roberto Sega

Research output: Contribution to journalArticlepeer-review

Abstract

The prevalence of the metabolic syndrome (National Cholesterol Education Program Adult Treatment Panel III criteria) and its relationships with daily life blood pressures, cardiac damage, and prognosis were determined in 2013 subjects from a Northern Italian population aged 25 to 74 years. Home blood pressure, 24-hour blood pressure, and left ventricular mass index (echocardiography) were also measured. Cardiovascular and noncardiovascular deaths were registered over 148 months. Metabolic syndrome was found in 16.2% of the sample, an office blood pressure elevation being the most frequent (95.4%) and the blood glucose abnormality the least frequent (31.5%) component. There was in metabolic syndrome a frequent elevation in home and/or 24-hour average blood pressure, as well as a greater left ventricular mass index and prevalence of left ventricular hypertrophy, which was manifest even when data were adjusted for between-group differences, including blood pressure. The adjusted risk of cardiovascular and all-cause mortality was greater in metabolic syndrome subjects (+71.0% and +37.0%; P

Original languageEnglish
Pages (from-to)40-47
Number of pages8
JournalHypertension
Volume49
Issue number1
DOIs
Publication statusPublished - Jan 2007

Keywords

  • Blood pressure
  • Cardiac hypertrophy
  • Cardiovascular morbidity
  • Cardiovascular mortality
  • Metabolic syndrome

ASJC Scopus subject areas

  • Internal Medicine

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