Metabolic syndrome in turner syndrome and relation between body composition and clinical, genetic, and ultrasonographic characteristics

Valeria Calcaterra, Paola Brambilla, Gabriella Carnevale Maffè, Catherine Klersy, Riccardo Albertini, Francesca Introzzi, Elena Bozzola, Mauro Bozzola, Daniela Larizza

Research output: Contribution to journalArticlepeer-review

Abstract

Background: An increased relative risk of diabetes, ischemic heart disease, atherosclerosis, and hypertension have been reported in Turner syndrome (TS) patients. No data are currently available on the prevalence of metabolic syndrome in TS subjects. We evaluated the frequency of metabolic syndrome in obese and nonobese patients with TS. Patients and Methods: We evaluated 85 TS patients (27.05±11.17 years). Obesity was defined as standard deviation score body mass index (SDS-BMI) ≥2 or BMI ≥30 kg/m2 in adult patients. We classified metabolic syndrome according to the International Diabetes Federation (IDF). Hepatic ultrasound was performed in all girls. Results: The prevalence of metabolic syndrome was 4.7% (12.5% obese and 4.3% nonobese, P=0.16) and associated with visceral adiposity (P=0.008). Abnormalities in glucose metabolism and hypertension were not associated with genetic or therapeutic factors. The karyotype 45,X was associated with atherogenic profile. Pathological waist circumference was more frequent in girls treated with estro-progestin (P=0.03). Evidence of fatty liver was associated with metabolic syndrome (P=0.03) and insulin resistance (P=0.05). Elevated liver enzymes were found in 15 subjects and were not related to treatment or ultrasound abnormalities. Conclusions: Prevalence of each component of metabolic syndrome in TS patients is partially influenced by genetic makeup and treatment. Hepatosteatosis was associated with metabolic syndrome and insulin resistance, but not to elevated liver enzymes.

Original languageEnglish
Pages (from-to)159-164
Number of pages6
JournalMetabolic Syndrome and Related Disorders
Volume12
Issue number3
DOIs
Publication statusPublished - Apr 1 2014

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Internal Medicine

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