Metabolic syndrome, insulin resistance, circadian disruption, antioxidants and pancreatic carcinoma: An overview

Aldo Giudice, Anna Crispo, Galdiero Massimiliano, Giovanni D'Arena, Mario Felice Tecce, Maria Grimaldi, Alfonso Amore, Emanuela Esposito, Maurizio Montella

Research output: Contribution to journalArticlepeer-review

Abstract

The incidence and number of deaths caused by pancreatic tumours have been gradually rising, while the incidence and mortality of other common cancers have been declining. Risk factors for this malignant disease include cigarette smoking, family history of chronic pancreatitis, advancing age, male sex, diabetes mellitus, obesity, non-0 blood group, a high-fat diet, alcohol consumption and possibly Helicobacter pylori and hepatitis B virus infections. Metabolic diseases have become the leading cause of death in many countries. Our paper serves as a focused and updated discussion about the development of novel preventive strategies for this deadly disease.

Original languageEnglish
Pages (from-to)73-77
Number of pages5
JournalJournal of Gastrointestinal and Liver Diseases
Volume23
Issue number1
Publication statusPublished - 2014

Keywords

  • Antioxidants
  • Circadian disruption
  • Insulin resistance
  • Metabolic syndrome
  • Pancreatic cancer

ASJC Scopus subject areas

  • Gastroenterology
  • Medicine(all)

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