Metabolic syndrome predicts lower functional recovery in female but not in male patients after an acute cardiac event

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Abstract

Aims: To evaluate whether metabolic syndrome MS has a gender dependent effect on the recovery of functional capacity in patients (pts) with coronary heart disease (CHD) undergoing a cardiac rehabilitation program. Methods and Results: We studied 286 CHD patients, age 66.2 ± 10.6 (median ± SD); M/F 187/99. Patients were divided into two groups according to the presence (MS, 48%) or not (nMS, 52%) of MS. MS was present in 48% of patients. Functional capacity was assessed by the distance walked at six minute walking test (6MWT), and by a maximal exercise test. Compared to patients without MS, those with MS walked a lower distance at 6MWT (438 ± 110 vs 408 ± 123 m; p <0.05), had a lower maximal exercise capacity (7.6 ± 1.8 vs 9.3 ± 1.2 MET; p <0.05) and a lower heart rate recovery (HRR) (16 ± 9 vs 22 ± 8; p <0.05). Male patients with or without MS had a similar degree of functional recovery (51%) while women with MS had a significantly lower recovery than nMS (20% vs 40%). In a multivariate logistic regression model, including body mass index, age, gender hypertension, ejection fraction and diabetes, MS predicted a reduced performance at 6MWT in the overall population (OR 1.4, 95% CI 1.7 to 2.4) and in women (OR 1.31; 95% CI 1.20-1.62), while it was not predictive in males. Conclusions: CAD patients with MS have lower functional recovery and HRR than nMS. However MS is an independent predictor of lower exercise capacity only in female gender.

Original languageEnglish
Pages (from-to)296-301
Number of pages6
JournalInternational Journal of Cardiology
Volume135
Issue number3
DOIs
Publication statusPublished - Jul 10 2009

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Coronary Disease
Heart Rate
Logistic Models
Exercise
Exercise Test
Walking
Body Mass Index
Hypertension
Population
Cardiac Rehabilitation

Keywords

  • Cardiac rehabilitation
  • Coronary artery disease
  • Exercise
  • Gender
  • Metabolic syndrome

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Cite this

@article{cf1dc9a31dba4846bc05d672de303d77,
title = "Metabolic syndrome predicts lower functional recovery in female but not in male patients after an acute cardiac event",
abstract = "Aims: To evaluate whether metabolic syndrome MS has a gender dependent effect on the recovery of functional capacity in patients (pts) with coronary heart disease (CHD) undergoing a cardiac rehabilitation program. Methods and Results: We studied 286 CHD patients, age 66.2 ± 10.6 (median ± SD); M/F 187/99. Patients were divided into two groups according to the presence (MS, 48{\%}) or not (nMS, 52{\%}) of MS. MS was present in 48{\%} of patients. Functional capacity was assessed by the distance walked at six minute walking test (6MWT), and by a maximal exercise test. Compared to patients without MS, those with MS walked a lower distance at 6MWT (438 ± 110 vs 408 ± 123 m; p <0.05), had a lower maximal exercise capacity (7.6 ± 1.8 vs 9.3 ± 1.2 MET; p <0.05) and a lower heart rate recovery (HRR) (16 ± 9 vs 22 ± 8; p <0.05). Male patients with or without MS had a similar degree of functional recovery (51{\%}) while women with MS had a significantly lower recovery than nMS (20{\%} vs 40{\%}). In a multivariate logistic regression model, including body mass index, age, gender hypertension, ejection fraction and diabetes, MS predicted a reduced performance at 6MWT in the overall population (OR 1.4, 95{\%} CI 1.7 to 2.4) and in women (OR 1.31; 95{\%} CI 1.20-1.62), while it was not predictive in males. Conclusions: CAD patients with MS have lower functional recovery and HRR than nMS. However MS is an independent predictor of lower exercise capacity only in female gender.",
keywords = "Cardiac rehabilitation, Coronary artery disease, Exercise, Gender, Metabolic syndrome",
author = "Giuseppe Caminiti and Maurizio Volterrani and Giuseppe Marazzi and Rosalba Massaro and Cristiana Vitale and Lucia Gatta and Caterina Mammi and Marco Miceli and Giuseppe Rosano",
year = "2009",
month = "7",
day = "10",
doi = "10.1016/j.ijcard.2008.03.094",
language = "English",
volume = "135",
pages = "296--301",
journal = "International Journal of Cardiology",
issn = "0167-5273",
publisher = "Elsevier Ireland Ltd",
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TY - JOUR

T1 - Metabolic syndrome predicts lower functional recovery in female but not in male patients after an acute cardiac event

AU - Caminiti, Giuseppe

AU - Volterrani, Maurizio

AU - Marazzi, Giuseppe

AU - Massaro, Rosalba

AU - Vitale, Cristiana

AU - Gatta, Lucia

AU - Mammi, Caterina

AU - Miceli, Marco

AU - Rosano, Giuseppe

PY - 2009/7/10

Y1 - 2009/7/10

N2 - Aims: To evaluate whether metabolic syndrome MS has a gender dependent effect on the recovery of functional capacity in patients (pts) with coronary heart disease (CHD) undergoing a cardiac rehabilitation program. Methods and Results: We studied 286 CHD patients, age 66.2 ± 10.6 (median ± SD); M/F 187/99. Patients were divided into two groups according to the presence (MS, 48%) or not (nMS, 52%) of MS. MS was present in 48% of patients. Functional capacity was assessed by the distance walked at six minute walking test (6MWT), and by a maximal exercise test. Compared to patients without MS, those with MS walked a lower distance at 6MWT (438 ± 110 vs 408 ± 123 m; p <0.05), had a lower maximal exercise capacity (7.6 ± 1.8 vs 9.3 ± 1.2 MET; p <0.05) and a lower heart rate recovery (HRR) (16 ± 9 vs 22 ± 8; p <0.05). Male patients with or without MS had a similar degree of functional recovery (51%) while women with MS had a significantly lower recovery than nMS (20% vs 40%). In a multivariate logistic regression model, including body mass index, age, gender hypertension, ejection fraction and diabetes, MS predicted a reduced performance at 6MWT in the overall population (OR 1.4, 95% CI 1.7 to 2.4) and in women (OR 1.31; 95% CI 1.20-1.62), while it was not predictive in males. Conclusions: CAD patients with MS have lower functional recovery and HRR than nMS. However MS is an independent predictor of lower exercise capacity only in female gender.

AB - Aims: To evaluate whether metabolic syndrome MS has a gender dependent effect on the recovery of functional capacity in patients (pts) with coronary heart disease (CHD) undergoing a cardiac rehabilitation program. Methods and Results: We studied 286 CHD patients, age 66.2 ± 10.6 (median ± SD); M/F 187/99. Patients were divided into two groups according to the presence (MS, 48%) or not (nMS, 52%) of MS. MS was present in 48% of patients. Functional capacity was assessed by the distance walked at six minute walking test (6MWT), and by a maximal exercise test. Compared to patients without MS, those with MS walked a lower distance at 6MWT (438 ± 110 vs 408 ± 123 m; p <0.05), had a lower maximal exercise capacity (7.6 ± 1.8 vs 9.3 ± 1.2 MET; p <0.05) and a lower heart rate recovery (HRR) (16 ± 9 vs 22 ± 8; p <0.05). Male patients with or without MS had a similar degree of functional recovery (51%) while women with MS had a significantly lower recovery than nMS (20% vs 40%). In a multivariate logistic regression model, including body mass index, age, gender hypertension, ejection fraction and diabetes, MS predicted a reduced performance at 6MWT in the overall population (OR 1.4, 95% CI 1.7 to 2.4) and in women (OR 1.31; 95% CI 1.20-1.62), while it was not predictive in males. Conclusions: CAD patients with MS have lower functional recovery and HRR than nMS. However MS is an independent predictor of lower exercise capacity only in female gender.

KW - Cardiac rehabilitation

KW - Coronary artery disease

KW - Exercise

KW - Gender

KW - Metabolic syndrome

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U2 - 10.1016/j.ijcard.2008.03.094

DO - 10.1016/j.ijcard.2008.03.094

M3 - Article

C2 - 18606472

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VL - 135

SP - 296

EP - 301

JO - International Journal of Cardiology

JF - International Journal of Cardiology

SN - 0167-5273

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