Abstract
Aims: To evaluate whether metabolic syndrome MS has a gender dependent effect on the recovery of functional capacity in patients (pts) with coronary heart disease (CHD) undergoing a cardiac rehabilitation program. Methods and Results: We studied 286 CHD patients, age 66.2 ± 10.6 (median ± SD); M/F 187/99. Patients were divided into two groups according to the presence (MS, 48%) or not (nMS, 52%) of MS. MS was present in 48% of patients. Functional capacity was assessed by the distance walked at six minute walking test (6MWT), and by a maximal exercise test. Compared to patients without MS, those with MS walked a lower distance at 6MWT (438 ± 110 vs 408 ± 123 m; p <0.05), had a lower maximal exercise capacity (7.6 ± 1.8 vs 9.3 ± 1.2 MET; p <0.05) and a lower heart rate recovery (HRR) (16 ± 9 vs 22 ± 8; p <0.05). Male patients with or without MS had a similar degree of functional recovery (51%) while women with MS had a significantly lower recovery than nMS (20% vs 40%). In a multivariate logistic regression model, including body mass index, age, gender hypertension, ejection fraction and diabetes, MS predicted a reduced performance at 6MWT in the overall population (OR 1.4, 95% CI 1.7 to 2.4) and in women (OR 1.31; 95% CI 1.20-1.62), while it was not predictive in males. Conclusions: CAD patients with MS have lower functional recovery and HRR than nMS. However MS is an independent predictor of lower exercise capacity only in female gender.
| Original language | English |
|---|---|
| Pages (from-to) | 296-301 |
| Number of pages | 6 |
| Journal | International Journal of Cardiology |
| Volume | 135 |
| Issue number | 3 |
| DOIs | |
| Publication status | Published - Jul 10 2009 |
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Keywords
- Cardiac rehabilitation
- Coronary artery disease
- Exercise
- Gender
- Metabolic syndrome
ASJC Scopus subject areas
- Cardiology and Cardiovascular Medicine
Cite this
Metabolic syndrome predicts lower functional recovery in female but not in male patients after an acute cardiac event. / Caminiti, Giuseppe; Volterrani, Maurizio; Marazzi, Giuseppe; Massaro, Rosalba; Vitale, Cristiana; Gatta, Lucia; Mammi, Caterina; Miceli, Marco; Rosano, Giuseppe.
In: International Journal of Cardiology, Vol. 135, No. 3, 10.07.2009, p. 296-301.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Metabolic syndrome predicts lower functional recovery in female but not in male patients after an acute cardiac event
AU - Caminiti, Giuseppe
AU - Volterrani, Maurizio
AU - Marazzi, Giuseppe
AU - Massaro, Rosalba
AU - Vitale, Cristiana
AU - Gatta, Lucia
AU - Mammi, Caterina
AU - Miceli, Marco
AU - Rosano, Giuseppe
PY - 2009/7/10
Y1 - 2009/7/10
N2 - Aims: To evaluate whether metabolic syndrome MS has a gender dependent effect on the recovery of functional capacity in patients (pts) with coronary heart disease (CHD) undergoing a cardiac rehabilitation program. Methods and Results: We studied 286 CHD patients, age 66.2 ± 10.6 (median ± SD); M/F 187/99. Patients were divided into two groups according to the presence (MS, 48%) or not (nMS, 52%) of MS. MS was present in 48% of patients. Functional capacity was assessed by the distance walked at six minute walking test (6MWT), and by a maximal exercise test. Compared to patients without MS, those with MS walked a lower distance at 6MWT (438 ± 110 vs 408 ± 123 m; p <0.05), had a lower maximal exercise capacity (7.6 ± 1.8 vs 9.3 ± 1.2 MET; p <0.05) and a lower heart rate recovery (HRR) (16 ± 9 vs 22 ± 8; p <0.05). Male patients with or without MS had a similar degree of functional recovery (51%) while women with MS had a significantly lower recovery than nMS (20% vs 40%). In a multivariate logistic regression model, including body mass index, age, gender hypertension, ejection fraction and diabetes, MS predicted a reduced performance at 6MWT in the overall population (OR 1.4, 95% CI 1.7 to 2.4) and in women (OR 1.31; 95% CI 1.20-1.62), while it was not predictive in males. Conclusions: CAD patients with MS have lower functional recovery and HRR than nMS. However MS is an independent predictor of lower exercise capacity only in female gender.
AB - Aims: To evaluate whether metabolic syndrome MS has a gender dependent effect on the recovery of functional capacity in patients (pts) with coronary heart disease (CHD) undergoing a cardiac rehabilitation program. Methods and Results: We studied 286 CHD patients, age 66.2 ± 10.6 (median ± SD); M/F 187/99. Patients were divided into two groups according to the presence (MS, 48%) or not (nMS, 52%) of MS. MS was present in 48% of patients. Functional capacity was assessed by the distance walked at six minute walking test (6MWT), and by a maximal exercise test. Compared to patients without MS, those with MS walked a lower distance at 6MWT (438 ± 110 vs 408 ± 123 m; p <0.05), had a lower maximal exercise capacity (7.6 ± 1.8 vs 9.3 ± 1.2 MET; p <0.05) and a lower heart rate recovery (HRR) (16 ± 9 vs 22 ± 8; p <0.05). Male patients with or without MS had a similar degree of functional recovery (51%) while women with MS had a significantly lower recovery than nMS (20% vs 40%). In a multivariate logistic regression model, including body mass index, age, gender hypertension, ejection fraction and diabetes, MS predicted a reduced performance at 6MWT in the overall population (OR 1.4, 95% CI 1.7 to 2.4) and in women (OR 1.31; 95% CI 1.20-1.62), while it was not predictive in males. Conclusions: CAD patients with MS have lower functional recovery and HRR than nMS. However MS is an independent predictor of lower exercise capacity only in female gender.
KW - Cardiac rehabilitation
KW - Coronary artery disease
KW - Exercise
KW - Gender
KW - Metabolic syndrome
UR - http://www.scopus.com/inward/record.url?scp=67349129798&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=67349129798&partnerID=8YFLogxK
U2 - 10.1016/j.ijcard.2008.03.094
DO - 10.1016/j.ijcard.2008.03.094
M3 - Article
C2 - 18606472
AN - SCOPUS:67349129798
VL - 135
SP - 296
EP - 301
JO - International Journal of Cardiology
JF - International Journal of Cardiology
SN - 0167-5273
IS - 3
ER -