Metabolic Syndrome Predicts Worse Perioperative Outcomes in Patients Treated With Partial Nephrectomy for Renal Cell Carcinoma

S. Luzzago, C. Palumbo, G. Rosiello, A. Pecoraro, M. Deuker, F. Stolzenbach, F.A. Mistretta, Z. Tian, G. Musi, E. Montanari, S.F. Shariat, F. Saad, A. Briganti, O. de Cobelli, P.I. Karakiewicz

Research output: Contribution to journalArticlepeer-review

Abstract

OBJECTIVE: To test the association between metabolic syndrome (MetS) and its components (high blood pressure, body mass index [BMI] ≥ 30, altered fasting glucose, low high-density lipoprotein cholesterol and high triglycerides) on perioperative outcomes after partial nephrectomy (PN). METHODS: Within the National Inpatient Sample database (2000-2015) we identified all PN patients. First, temporal trends of MetS were reported. Second, the effect of MetS components was tested in multivariable logistic regression models predicting overall and specific perioperative complications. Third, we tested for dose-response from the concomitant effect of multiple MetS components. All models were weighted and adjusted for clustering, as well as all available patient and hospital characteristics. RESULTS: Of 25,875 patients: (1) 59.3% had high blood pressure, (2) 14.7% had BMI ≥ 30, (3) 21.7% had altered fasting glucose, (4) 20.2% had high triglycerides, and (5)
Original languageEnglish
Pages (from-to)91-97
Number of pages7
JournalUrology
Volume140
DOIs
Publication statusPublished - 2020

Keywords

  • glucose
  • high density lipoprotein cholesterol
  • triacylglycerol
  • adult
  • aged
  • Article
  • blood transfusion
  • body mass
  • cancer prognosis
  • cancer surgery
  • controlled study
  • fasting
  • female
  • human
  • hypertension
  • major clinical study
  • male
  • metabolic syndrome X
  • partial nephrectomy
  • perioperative period
  • peroperative complication
  • priority journal
  • renal cell carcinoma
  • treatment outcome

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