Metabolism and autoimmune responses: The microRNA connection

Alessandra Colamatteo, Teresa Micillo, Sara Bruzzaniti, Clorinda Fusco, Silvia Garavelli, Veronica De Rosa, Mario Galgani, Maria Immacolata Spagnuolo, Francesca Di Rella, Annibale A. Puca, Paola de Candia, Giuseppe Matarese

Research output: Contribution to journalReview article

Abstract

Distinct metabolic pathways are known to regulate growth, differentiation, survival, and activation of immune cells by providing energy and specific biosynthetic precursors. Compelling experimental evidence demonstrates that effector T cell functions are coupled with profound changes in cellular metabolism. Importantly, the effector T cell-dependent “anti-self” response characterizing the autoimmune diseases is accompanied by significant metabolic alterations. MicroRNAs (miRNAs), evolutionary conserved small non-coding RNA molecules that affect gene expression by binding to target messenger RNAs, are now known to regulate multiple functions of effector T cells, including the strength of their activation, thus contributing to immune homeostasis. In this review, we will examine the most recent studies that describe miRNA direct involvement in the metabolic reprogramming that marks effector T cell functions. In particular, we will focus on the work showing a connection between miRNA regulatory function and the molecular network dysregulation that leads to metabolic pathway derangement in autoimmunity. Finally, we will also speculate on the possibility that the interplay between miRNAs and metabolism in T cells may help identify novel miRNA-based therapeutic strategies to treat effector T cell immunometabolic alterations in pathological conditions such as autoimmunity and chronic inflammation.

Original languageEnglish
Article number1969
JournalFrontiers in Immunology
Volume10
Issue numberAUG
DOIs
Publication statusPublished - Jan 1 2019

Fingerprint

MicroRNAs
Autoimmunity
T-Lymphocytes
Metabolic Networks and Pathways
Small Untranslated RNA
Autoimmune Diseases
Homeostasis
Inflammation
Gene Expression
Messenger RNA
Growth

Keywords

  • Autoimmune diseases
  • Immunometabolism
  • Metabolic regulation
  • MiRNAs
  • T cells

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

Cite this

Colamatteo, A., Micillo, T., Bruzzaniti, S., Fusco, C., Garavelli, S., De Rosa, V., ... Matarese, G. (2019). Metabolism and autoimmune responses: The microRNA connection. Frontiers in Immunology, 10(AUG), [1969]. https://doi.org/10.3389/fimmu.2019.01969

Metabolism and autoimmune responses : The microRNA connection. / Colamatteo, Alessandra; Micillo, Teresa; Bruzzaniti, Sara; Fusco, Clorinda; Garavelli, Silvia; De Rosa, Veronica; Galgani, Mario; Spagnuolo, Maria Immacolata; Di Rella, Francesca; Puca, Annibale A.; de Candia, Paola; Matarese, Giuseppe.

In: Frontiers in Immunology, Vol. 10, No. AUG, 1969, 01.01.2019.

Research output: Contribution to journalReview article

Colamatteo, A, Micillo, T, Bruzzaniti, S, Fusco, C, Garavelli, S, De Rosa, V, Galgani, M, Spagnuolo, MI, Di Rella, F, Puca, AA, de Candia, P & Matarese, G 2019, 'Metabolism and autoimmune responses: The microRNA connection', Frontiers in Immunology, vol. 10, no. AUG, 1969. https://doi.org/10.3389/fimmu.2019.01969
Colamatteo A, Micillo T, Bruzzaniti S, Fusco C, Garavelli S, De Rosa V et al. Metabolism and autoimmune responses: The microRNA connection. Frontiers in Immunology. 2019 Jan 1;10(AUG). 1969. https://doi.org/10.3389/fimmu.2019.01969
Colamatteo, Alessandra ; Micillo, Teresa ; Bruzzaniti, Sara ; Fusco, Clorinda ; Garavelli, Silvia ; De Rosa, Veronica ; Galgani, Mario ; Spagnuolo, Maria Immacolata ; Di Rella, Francesca ; Puca, Annibale A. ; de Candia, Paola ; Matarese, Giuseppe. / Metabolism and autoimmune responses : The microRNA connection. In: Frontiers in Immunology. 2019 ; Vol. 10, No. AUG.
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