Metabolism, LXR/LXR ligands, and tumor immune escape

Research output: Contribution to journalArticlepeer-review

Abstract

The mechanisms of tumor immune evasion have gainedincreasing interest among the tumor immunologists,because of their ability to suppress spontaneous andimmunotherapy-elicited antitumor responses. Recentstudies clearly show that the deletion of cells/moleculesinvolved in tumor evasion is capable of restoringantitumor immune responses, ultimately leading to tumorrejection in mouse tumor models. These studiesfurther support and strengthen the idea to target notonly the cancer cell-intrinsic defects but also those affectingcells of the microenvironment, such as immunecells. The alterations of cancer cell metabolism are alsoemerging as important regulators of immune cell function,with particular emphasis on immune-escapemechanisms. Indeed, intermediate or final products ofcancer cell metabolism may interfere with the functionof immune cells infiltrating the tumor microenvironment.This review will focus on the role of cholesterol metabolism,with particular emphasis on the axis LXR/LXR ligands.This axis has been shown to affect DC migrationto lymphoid organs, thus dampening the induction ofsuccessful antitumor responses. Finally, we will discusswhether this pathway may interfere with other immunecells infiltrating tumors and how to improve spontaneousand immunotherapy-based antitumor responses bycounteracting this immune-escape mechanism.

Original languageEnglish
Pages (from-to)673-679
Number of pages7
JournalJournal of Leukocyte Biology
Volume90
Issue number4
DOIs
Publication statusPublished - Oct 2011

Keywords

  • Immune escapeantitumor response
  • Leukocyte tumor interactions
  • Lymph node

ASJC Scopus subject areas

  • Cell Biology
  • Immunology

Fingerprint Dive into the research topics of 'Metabolism, LXR/LXR ligands, and tumor immune escape'. Together they form a unique fingerprint.

Cite this