Metabolism of exogenous cortisol in humans-I. Diurnal variation in plasma disappearance rate

P. L. Morselli, V. Marc, S. Garattini, M. Zaccala

Research output: Contribution to journalArticle

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Abstract

A variation in the rate of disappearance from plasma, at different times of the day, has been observed for exogenous Cortisol in humans after i.v. administration. This appears to correlate with the endogenous cortisol plasma levels. The possibility of a circadian fluctuation of drug metabolizing enzyme activities in man is discussed.

Original languageEnglish
Pages (from-to)1643-1647
Number of pages5
JournalBiochemical Pharmacology
Volume19
Issue number5
DOIs
Publication statusPublished - 1970

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Metabolism
Hydrocortisone
Plasmas
Enzyme activity
Enzymes
Pharmaceutical Preparations

ASJC Scopus subject areas

  • Pharmacology

Cite this

Metabolism of exogenous cortisol in humans-I. Diurnal variation in plasma disappearance rate. / Morselli, P. L.; Marc, V.; Garattini, S.; Zaccala, M.

In: Biochemical Pharmacology, Vol. 19, No. 5, 1970, p. 1643-1647.

Research output: Contribution to journalArticle

Morselli, P. L. ; Marc, V. ; Garattini, S. ; Zaccala, M. / Metabolism of exogenous cortisol in humans-I. Diurnal variation in plasma disappearance rate. In: Biochemical Pharmacology. 1970 ; Vol. 19, No. 5. pp. 1643-1647.
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