Metabolism of human gliomas: Assessment with H-1 MR spectroscopy and F-18 fluorodeoxyglucose PET

Jeffry R. Alger, Joseph A. Frank, Alberto Bizzi, Michael J. Fulham, Bryan X. DeSouza, Michael O. Duhaney, Susan W. Inscoe, Jeanette L. Black, Peter C M Van Zijl, Chrit T W Moonen, Giovanni Di Chiro

Research output: Contribution to journalArticle

209 Citations (Scopus)

Abstract

Localized hydrogen-1 magnetic resonance (MR) spectroscopy and fluorine-18 fluorodeoxyglucose (FDG) positron emission tomography (PET) were employed to obtain metabolic information from intracranial gliomas. Advantages and difficulties associated with comparison of results from the two modalities were realized. Forty patients were studied with H-1 MR spectroscopy. MR signal intensities from lactate, N-acetylaspartate (NAA), choline, and creatine from a volume of interest containing the tumor and a contralateral volume were obtained and evaluated. NAA signal intensities were generally decreased in the tumor spectra, and choline signal intensities were elevated. H-1 MR spectroscopy was unsuccessful in eight patients, and FDG PET scans were not obtained in four of the patients with successful MR spectroscopic examinations. Lactate signal intensity was detected in 10 of the 28 patients who had successful H-1 MR spectroscopic and FDG PET studies. Lactate signal intensities were observed in lesions shown at FDG PET to be hypermetabolic, as well as in lesions found to be hypometabolic.

Original languageEnglish
Pages (from-to)633-641
Number of pages9
JournalRadiology
Volume177
Issue number3
Publication statusPublished - Dec 1990

Fingerprint

Fluorodeoxyglucose F18
Glioma
Positron-Emission Tomography
Magnetic Resonance Spectroscopy
Lactic Acid
Choline
Creatine
Hydrogen
Neoplasms

Keywords

  • Brain neoplasms, 13.36
  • Brain neoplasms, CT, 13.1211
  • Brain neoplasms, MR studies, 13.1214
  • Emission CT, 13.1211
  • Magnetic resonance (MR), fluorine studies, 13.1229
  • Magnetic resonance (MR), spectroscopy

ASJC Scopus subject areas

  • Radiological and Ultrasound Technology

Cite this

Alger, J. R., Frank, J. A., Bizzi, A., Fulham, M. J., DeSouza, B. X., Duhaney, M. O., ... Di Chiro, G. (1990). Metabolism of human gliomas: Assessment with H-1 MR spectroscopy and F-18 fluorodeoxyglucose PET. Radiology, 177(3), 633-641.

Metabolism of human gliomas : Assessment with H-1 MR spectroscopy and F-18 fluorodeoxyglucose PET. / Alger, Jeffry R.; Frank, Joseph A.; Bizzi, Alberto; Fulham, Michael J.; DeSouza, Bryan X.; Duhaney, Michael O.; Inscoe, Susan W.; Black, Jeanette L.; Van Zijl, Peter C M; Moonen, Chrit T W; Di Chiro, Giovanni.

In: Radiology, Vol. 177, No. 3, 12.1990, p. 633-641.

Research output: Contribution to journalArticle

Alger, JR, Frank, JA, Bizzi, A, Fulham, MJ, DeSouza, BX, Duhaney, MO, Inscoe, SW, Black, JL, Van Zijl, PCM, Moonen, CTW & Di Chiro, G 1990, 'Metabolism of human gliomas: Assessment with H-1 MR spectroscopy and F-18 fluorodeoxyglucose PET', Radiology, vol. 177, no. 3, pp. 633-641.
Alger JR, Frank JA, Bizzi A, Fulham MJ, DeSouza BX, Duhaney MO et al. Metabolism of human gliomas: Assessment with H-1 MR spectroscopy and F-18 fluorodeoxyglucose PET. Radiology. 1990 Dec;177(3):633-641.
Alger, Jeffry R. ; Frank, Joseph A. ; Bizzi, Alberto ; Fulham, Michael J. ; DeSouza, Bryan X. ; Duhaney, Michael O. ; Inscoe, Susan W. ; Black, Jeanette L. ; Van Zijl, Peter C M ; Moonen, Chrit T W ; Di Chiro, Giovanni. / Metabolism of human gliomas : Assessment with H-1 MR spectroscopy and F-18 fluorodeoxyglucose PET. In: Radiology. 1990 ; Vol. 177, No. 3. pp. 633-641.
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