Metabolite changes in normal appearing cervical spinal cord in two patients with multiple sclerosis. A proton MR spectroscopic analysis

M. Maffei, A. F. Marliani, F. Salvi, V. Clementi, R. Agati, M. Leonardi

Research output: Contribution to journalArticle

Abstract

We describe two cases of multiple sclerosis (MS) analyzed with Proton MR Spectroscopy (1H-MRS) with the voxel placed along the main axis of the normal appearing cervical spinal cord over three main space planes, orthogonally set. Relative concentrations expressed by the absolute concentration ratios of total NAA (tNAA), choline (Cho), myo-inositol (mI) and creatine plus phosphocreatine (Cr) were compared with the metabolites of ten healthy volunteers. We found a significant increase in mI/Cr and a small increase in Cho/Cr in the first patient, whereas the second patient had a decrease in NAA/Cr and NAA/Cho ratios. 1H-MRS will disclose biochemical changes in MS, even in normal appearing spinal cord, as already described in normal appearing cerebral tissue: these biochemical changes may provide significant information on disease prognosis.

Original languageEnglish
Pages (from-to)228-235
Number of pages8
JournalNeuroradiology Journal
Volume21
Issue number2
Publication statusPublished - Apr 2008

Fingerprint

Choline
Multiple Sclerosis
Protons
Inositol
Phosphocreatine
Creatine
Spinal Cord
Healthy Volunteers
Magnetic Resonance Spectroscopy
Cervical Cord
Proton Magnetic Resonance Spectroscopy

Keywords

  • 3 Tesla
  • Metabolite quantification
  • Multiple sclerosis
  • Proton magnetic resonance spectroscopy
  • Spinal cord

ASJC Scopus subject areas

  • Clinical Neurology
  • Radiology Nuclear Medicine and imaging

Cite this

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AU - Maffei, M.

AU - Marliani, A. F.

AU - Salvi, F.

AU - Clementi, V.

AU - Agati, R.

AU - Leonardi, M.

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N2 - We describe two cases of multiple sclerosis (MS) analyzed with Proton MR Spectroscopy (1H-MRS) with the voxel placed along the main axis of the normal appearing cervical spinal cord over three main space planes, orthogonally set. Relative concentrations expressed by the absolute concentration ratios of total NAA (tNAA), choline (Cho), myo-inositol (mI) and creatine plus phosphocreatine (Cr) were compared with the metabolites of ten healthy volunteers. We found a significant increase in mI/Cr and a small increase in Cho/Cr in the first patient, whereas the second patient had a decrease in NAA/Cr and NAA/Cho ratios. 1H-MRS will disclose biochemical changes in MS, even in normal appearing spinal cord, as already described in normal appearing cerebral tissue: these biochemical changes may provide significant information on disease prognosis.

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