Metabolomic does not predict response to cardiac resynchronization therapy in patients with heart failure

Luigi Padeletti, Pietro A. Modesti, Stella Cartei, Luca Checchi, Giuseppe Ricciardi, Paolo Pieragnoli, Stefania Sacchi, Margherita Padeletti, Brunetto Alterini, Pietro Pantaleo, Xiaoyu Hu, Leonardo Tenori, Claudio Luchinat

Research output: Contribution to journalArticlepeer-review

Abstract

AIMS: Metabolomic, a systematic study of metabolites, may be a useful tool in understanding the pathological processes that underlie the occurrence and progression of a disease. We hypothesized that metabolomic would be helpful in assessing a specific pattern in heart failure patients, also according to the underlining causes and in defining, prior to device implantation, the responder and nonresponder patient to cardiac resynchronization therapy (CRT). METHODS: In this prospective study, blood and urine samples were collected from 32 heart failure patients who underwent CRT. Clinical, electrocardiography and echocardiographic evaluation was performed in each patient before CRT and after 6 months of follow-up. Thirty-nine age and sex-matched healthy individuals were chosen as control group. For each sample, 1H-NMR spectra, Nuclear Overhauser Enhancement Spectroscopy, Carr-Purcell-Meiboom-Gill and diffusion edited spectra were measured. RESULTS: A different metabolomic fingerprint was demonstrated in heart failure patients compared to healthy controls with high accuracy level. Metabolomics fingerprint was similar between patients with ischemic and nonischemic dilated cardiomyopathy. At 6-month follow-up, metabolomic fingerprint was different from baseline. At follow-up, heart failure patients' metabolomic fingerprint remained significantly different from that of healthy controls, and accuracy of cause discrimination remained low. Responders and nonresponders had a similar metabolic fingerprint at baseline and after 6 months of CRT. CONCLUSION: It is possible to identify a metabolomic fingerprint characterizing heart failure patients candidate to CRT, it is independent of the different causes of the disease and it is not predictive of the response to CRT.

Original languageEnglish
Pages (from-to)295-300
Number of pages6
JournalJournal of Cardiovascular Medicine
Volume15
Issue number4
DOIs
Publication statusPublished - 2014

Keywords

  • cardiac resynchronization therapy
  • heart failure
  • metabolomic

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Medicine(all)

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