TY - JOUR
T1 - Metabolomic profiling for the identification of novel diagnostic markers in prostate cancer
AU - Lucarelli, Giuseppe
AU - Rutigliano, Monica
AU - Galleggiante, Vanessa
AU - Giglio, Andrea
AU - Palazzo, Silvano
AU - Ferro, Matteo
AU - Simone, Cristiano
AU - Bettocchi, Carlo
AU - Battaglia, Michele
AU - Ditonno, Pasquale
PY - 2015/9/2
Y1 - 2015/9/2
N2 - Metabolomic profiling offers a powerful methodology for understanding the perturbations of biochemical systems occurring during a disease process. During neoplastic transformation, prostate cells undergo metabolic reprogramming to satisfy the demands of growth and proliferation. An early event in prostate cell transformation is the loss of capacity to accumulate zinc. This change is associated with a higher energy efficiency and increased lipid biosynthesis for cellular proliferation, membrane formation and cell signaling. Moreover, recent studies have shown that sarcosine, an N-methyl derivative of glycine, was significantly increased during disease progression from normal to localized to metastatic prostate cancer. Mapping the metabolomic profiles to their respective biochemical pathways showed an upregulation of androgen-induced protein synthesis, an increased amino acid metabolism and a perturbation of nitrogen breakdown pathways, along with high total choline-containing compounds and phosphocholine levels. In this review, the role of emerging biomarkers is summarized, based on the current understanding of the prostate cancer metabolome.
AB - Metabolomic profiling offers a powerful methodology for understanding the perturbations of biochemical systems occurring during a disease process. During neoplastic transformation, prostate cells undergo metabolic reprogramming to satisfy the demands of growth and proliferation. An early event in prostate cell transformation is the loss of capacity to accumulate zinc. This change is associated with a higher energy efficiency and increased lipid biosynthesis for cellular proliferation, membrane formation and cell signaling. Moreover, recent studies have shown that sarcosine, an N-methyl derivative of glycine, was significantly increased during disease progression from normal to localized to metastatic prostate cancer. Mapping the metabolomic profiles to their respective biochemical pathways showed an upregulation of androgen-induced protein synthesis, an increased amino acid metabolism and a perturbation of nitrogen breakdown pathways, along with high total choline-containing compounds and phosphocholine levels. In this review, the role of emerging biomarkers is summarized, based on the current understanding of the prostate cancer metabolome.
KW - androgen receptor
KW - biomarker
KW - metabolomics
KW - prostate cancer
KW - sarcosine
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U2 - 10.1586/14737159.2015.1069711
DO - 10.1586/14737159.2015.1069711
M3 - Article
C2 - 26174441
AN - SCOPUS:84940528365
VL - 15
SP - 1211
EP - 1224
JO - Expert Review of Molecular Diagnostics
JF - Expert Review of Molecular Diagnostics
SN - 1473-7159
IS - 9
ER -