TY - JOUR
T1 - Metabolomic profiling for the identification of novel diagnostic markers and therapeutic targets in prostate cancer
T2 - an update
AU - Lucarelli, Giuseppe
AU - Loizzo, Davide
AU - Ferro, Matteo
AU - Rutigliano, Monica
AU - Vartolomei, Mihai Dorin
AU - Cantiello, Francesco
AU - Buonerba, Carlo
AU - Di Lorenzo, Giuseppe
AU - Terracciano, Daniela
AU - De Cobelli, Ottavio
AU - Bettocchi, Carlo
AU - Ditonno, Pasquale
AU - Battaglia, Michele
PY - 2019/5/4
Y1 - 2019/5/4
N2 - Introduction: An altered metabolic regulation is involved in the development and progression of different cancer types. As well as this, many genes associated with tumors are shown to have an important role in control of the metabolism. The incidence of prostate cancer (PCa) is increased in men with metabolic disorders. In particular, obesity is an established risk factor for PCa. An increased body mass index correlates with aggressive disease, and a higher risk of biochemical recurrence and prostate cancer-specific mortality. Increased lipogenesis is also one of the most significant events in PCa metabolism reprogramming. Areas covered: In this article, we provide an updated review of the current understanding of the PCa metabolome and evaluate the possibility of unveiling novel therapeutic targets. Expert opinion: Obesity is an established risk factor for PCa, and an increased BMI correlates with aggressive disease, and a higher risk of biochemical recurrence and prostate cancer-specific mortality. PCa metabolome is characterized by the accumulation of metabolic intermediates and an increased expression of genes in the tricarboxylic acid cycle, the induction of de novo lipogenesis and cholesterogenesis. PCa cells can induce different alterations in their microenvironment by modulating the crosstalk between cancer and stromal cells.
AB - Introduction: An altered metabolic regulation is involved in the development and progression of different cancer types. As well as this, many genes associated with tumors are shown to have an important role in control of the metabolism. The incidence of prostate cancer (PCa) is increased in men with metabolic disorders. In particular, obesity is an established risk factor for PCa. An increased body mass index correlates with aggressive disease, and a higher risk of biochemical recurrence and prostate cancer-specific mortality. Increased lipogenesis is also one of the most significant events in PCa metabolism reprogramming. Areas covered: In this article, we provide an updated review of the current understanding of the PCa metabolome and evaluate the possibility of unveiling novel therapeutic targets. Expert opinion: Obesity is an established risk factor for PCa, and an increased BMI correlates with aggressive disease, and a higher risk of biochemical recurrence and prostate cancer-specific mortality. PCa metabolome is characterized by the accumulation of metabolic intermediates and an increased expression of genes in the tricarboxylic acid cycle, the induction of de novo lipogenesis and cholesterogenesis. PCa cells can induce different alterations in their microenvironment by modulating the crosstalk between cancer and stromal cells.
KW - cholesterol
KW - fatty acids
KW - lipid metabolism
KW - Metabolomics
KW - prostate cancer
KW - SREBP
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U2 - 10.1080/14737159.2019.1604223
DO - 10.1080/14737159.2019.1604223
M3 - Review article
C2 - 30957583
AN - SCOPUS:85065810297
VL - 19
SP - 377
EP - 387
JO - Expert Review of Molecular Diagnostics
JF - Expert Review of Molecular Diagnostics
SN - 1473-7159
IS - 5
ER -