Metabolomic profiling for the identification of novel diagnostic markers and therapeutic targets in prostate cancer: an update

Giuseppe Lucarelli, Davide Loizzo, Matteo Ferro, Monica Rutigliano, Mihai Dorin Vartolomei, Francesco Cantiello, Carlo Buonerba, Giuseppe Di Lorenzo, Daniela Terracciano, Ottavio De Cobelli, Carlo Bettocchi, Pasquale Ditonno, Michele Battaglia

Research output: Contribution to journalReview articlepeer-review

Abstract

Introduction: An altered metabolic regulation is involved in the development and progression of different cancer types. As well as this, many genes associated with tumors are shown to have an important role in control of the metabolism. The incidence of prostate cancer (PCa) is increased in men with metabolic disorders. In particular, obesity is an established risk factor for PCa. An increased body mass index correlates with aggressive disease, and a higher risk of biochemical recurrence and prostate cancer-specific mortality. Increased lipogenesis is also one of the most significant events in PCa metabolism reprogramming. Areas covered: In this article, we provide an updated review of the current understanding of the PCa metabolome and evaluate the possibility of unveiling novel therapeutic targets. Expert opinion: Obesity is an established risk factor for PCa, and an increased BMI correlates with aggressive disease, and a higher risk of biochemical recurrence and prostate cancer-specific mortality. PCa metabolome is characterized by the accumulation of metabolic intermediates and an increased expression of genes in the tricarboxylic acid cycle, the induction of de novo lipogenesis and cholesterogenesis. PCa cells can induce different alterations in their microenvironment by modulating the crosstalk between cancer and stromal cells.

Original languageEnglish
Pages (from-to)377-387
Number of pages11
JournalExpert Review of Molecular Diagnostics
Volume19
Issue number5
DOIs
Publication statusPublished - May 4 2019

Keywords

  • cholesterol
  • fatty acids
  • lipid metabolism
  • Metabolomics
  • prostate cancer
  • SREBP

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Molecular Medicine
  • Molecular Biology
  • Genetics

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