Metabolomics technology and their application to the study of the viral infection

Antonio Noto, Angelica Dessi, Melania Puddu, Michele Mussap, Vassilios Fanos

Research output: Contribution to journalArticle

Abstract

Objective: In the present review article we have summarized the use of the metabolomics approach to study the metabolic modifications occurring in several bio-fluids due to viral infections. The aim is to highlight the ability of metabolomics to find early fingerprints, which are related to the infections.

Methods: The 1H-NMR, UHPLC/MS/MS2, UPLC/ESI-SYNAPT-HDMS, UPLC-Q-TOF-HDMS analyses were used for the determination of several metabolites representative of the viral infections. The data were analyzed by Principal Component Analysis (PCA), Partial Least Square Discriminant Analysis (PLS-DA) and by regression techniques.

Results: The major changes were related to nucleotide, carbohydrates, lipids and amino acid metabolisms.

Conclusions: The metabolomics approach could be considered a viable option for characterization of the viral infection and for detecting on going differences in the bio-fluids composition.

Original languageEnglish
Pages (from-to)53-57
Number of pages5
JournalJournal of Maternal-Fetal and Neonatal Medicine
Volume27
DOIs
Publication statusPublished - Oct 1 2014

Keywords

  • Metabolism
  • Metabolites
  • Metabolomics
  • Multivariate statistical analysis
  • Viral infection.

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Obstetrics and Gynaecology
  • Medicine(all)

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