Metabonomics and population studies: Age-related amino acids excretion and inferring networks through the study of urine samples in two Italian isolated populations

Pio D'Adamo, Sheila Ulivi, Amerigo Beneduci, Gabriele Pontoni, Giovambattista Capasso, Carmela Lanzara, Gilberto Andrighetto, Uros Hladnik, Virginia Nunes, Manuel Palacin, Paolo Gasparini

Research output: Contribution to journalArticle

Abstract

The study of two different Italian isolated populations was combined with a metabonomic approach to better understand tubular handling of amino acids. Levels of amino acids and metabolites have been analyzed by Nucleic Magnetic Resonance and expressed as ratio vs urinary creatinine concentration (mmol/mol). For most of the amino acids there is an age-related U shape pattern of excretion, with the peaks during childhood and old age, and a significant reduction in the adult age. Hierarchical cluster analysis has clearly identified three groups clustering the same amino acids: His, Thr and Ala (group one); Gly and Phe (group two) and a third larger one. Results have been further confirmed by factor and regression analysis, and used to confirm and, in some cases, infer new amino acids networks. As a matter of facts, the identification of strong evidences for clustering of urine excretion of several neutral amino acids suggests the predominant impact of relevant and common transporters

Original languageEnglish
Pages (from-to)65-73
Number of pages9
JournalAmino Acids
Volume38
Issue number1
DOIs
Publication statusPublished - Jan 2010

Keywords

  • Amino acids
  • Metabonomics
  • Population studies
  • Tubular handling

ASJC Scopus subject areas

  • Biochemistry
  • Clinical Biochemistry
  • Organic Chemistry

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