Metabotrophic potential of neurotrophins

Implication in obesity and related diseases?

George N. Chaldakov, Marco Fiore, Mariyana G. Hristova, Luigi Aloe

Research output: Contribution to journalArticle

48 Citations (Scopus)

Abstract

In addition to their stimulatory action on neuronal differentiation and survival, the neurotrophins nerve growth factor (NGF) and brain-derived neurotrophic factor (BDNF) improve glucose and lipid metabolism and control energy balance and feeding behavior. These latter activities are referred to here as the metabotrophic potential of neurotrophins. We recently reported that circulating NGF and BDNF levels are reduced in the metabolic syndrome and in acute coronary syndromes, and that the tissue content of NGF is reduced in atherosclerotic coronary arteries. Thus we hypothesize that a metabotrophic deficit due to reduction of neurotrophin availability may be implicated in the pathogenesis of obesity and related metabolic diseases, such as metabolic syndrome, type 2 diabetes, and atherosclerosis. The metabotrophic deficit hypothesis also considers metabolism-related beneficial effects exerted by other neurotrophic factors, particularly ciliary neurotrophic factor, leukemia inhibitory factor, and bone morphogenetic proteins.

Original languageEnglish
JournalMedical Science Monitor
Volume9
Issue number10
Publication statusPublished - Oct 2003

Fingerprint

Nerve Growth Factors
Nerve Growth Factor
Obesity
Brain-Derived Neurotrophic Factor
Ciliary Neurotrophic Factor
Leukemia Inhibitory Factor
Bone Morphogenetic Proteins
Metabolic Diseases
Feeding Behavior
Acute Coronary Syndrome
Lipid Metabolism
Type 2 Diabetes Mellitus
Atherosclerosis
Coronary Vessels
Glucose

Keywords

  • Atherosclerosis
  • BDNF
  • Diabetes
  • Metabolic syndrome
  • NGF

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Chaldakov, G. N., Fiore, M., Hristova, M. G., & Aloe, L. (2003). Metabotrophic potential of neurotrophins: Implication in obesity and related diseases? Medical Science Monitor, 9(10).

Metabotrophic potential of neurotrophins : Implication in obesity and related diseases? / Chaldakov, George N.; Fiore, Marco; Hristova, Mariyana G.; Aloe, Luigi.

In: Medical Science Monitor, Vol. 9, No. 10, 10.2003.

Research output: Contribution to journalArticle

Chaldakov, GN, Fiore, M, Hristova, MG & Aloe, L 2003, 'Metabotrophic potential of neurotrophins: Implication in obesity and related diseases?', Medical Science Monitor, vol. 9, no. 10.
Chaldakov, George N. ; Fiore, Marco ; Hristova, Mariyana G. ; Aloe, Luigi. / Metabotrophic potential of neurotrophins : Implication in obesity and related diseases?. In: Medical Science Monitor. 2003 ; Vol. 9, No. 10.
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