Metabotropic glutamate receptor agonists stimulate polyphosphoinositide hydrolysis in primary cultures of rat hepatocytes

Francesc Sureda, Agata Copani, Valeria Bruno, Thomas Knöpfel, Gainer Meltzger, Ferdinando Nicoletti

Research output: Contribution to journalArticle

20 Citations (Scopus)

Abstract

The metabotropic glutamate (mGlu) receptor agonists, quisqualate and (1S,3R)-1-aminocyclopentane-1,3-dicarboxylic acid (ACPD), but not (RS)-3,5-dihydroxyphenylglycine or (2S,3S,4S)-α-(carboxycyclopropyl)glycine stimulated [3H]inositolmonophosphate ([3H]InsP) formation in primary cultures of rat hepatocytes. 1S,3R-ACPD-stimulated [3H]InsP formation was inhibited by α-methyl-4-carboxyphenylglycine, indicating that cultured hepatocytes express functional mGlu receptors coupled to polyphosphoinositide hydrolysis. The identity of these receptors is not similar to that of any of the known mGlu receptor subtypes characterized in heterologous expression systems.

Original languageEnglish
JournalEuropean Journal of Pharmacology
Volume338
Issue number2
DOIs
Publication statusPublished - Nov 5 1997

Fingerprint

Excitatory Amino Acid Agonists
Phosphatidylinositol Phosphates
Metabotropic Glutamate Receptors
Hepatocytes
Hydrolysis
Quisqualic Acid
Glycine
1-amino-1,3-dicarboxycyclopentane

Keywords

  • Hepatocyte cultured
  • Metabotropic glutamate receptor
  • Polyphosphoinositide hydrolysis

ASJC Scopus subject areas

  • Cellular and Molecular Neuroscience
  • Pharmacology

Cite this

Metabotropic glutamate receptor agonists stimulate polyphosphoinositide hydrolysis in primary cultures of rat hepatocytes. / Sureda, Francesc; Copani, Agata; Bruno, Valeria; Knöpfel, Thomas; Meltzger, Gainer; Nicoletti, Ferdinando.

In: European Journal of Pharmacology, Vol. 338, No. 2, 05.11.1997.

Research output: Contribution to journalArticle

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AU - Nicoletti, Ferdinando

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