Metabotropic glutamate receptors: A new target for the therapy of neurodegenerative disorders?

F. Nicoletti, V. Bruno, A. Copani, G. Casabona, T. Knöpfel

Research output: Contribution to journalArticlepeer-review

Abstract

Metabotropic glutamate (mGlu) receptors are a large, heterogeneous family of G-protein coupled receptors, which modulate excitatory synaptic transmission through various transduction pathways. Evidence is now accumulating that individual mGlu-receptor subtypes mediate distinct, facilitatory (group I subtypes) or inhibitory (group II and group III subtypes), actions on neurodegenerative processes. Drugs interacting with mGlu receptors are expected to influence both the induction and progression of neuronal degeneration without hampering the efficiency of fast excitatory synaptic transmission. For these reasons, mGlu receptors can be considered as promising drug targets in the experimental therapy of acute or chronic neurodegenerative diseases.

Original languageEnglish
Pages (from-to)267-271
Number of pages5
JournalTrends in Neurosciences
Volume19
Issue number7
DOIs
Publication statusPublished - Jul 1996

ASJC Scopus subject areas

  • Neuroscience(all)

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