Metabotropic glutamate receptors in the basal ganglia motor circuit

P. Jeffrey Conn, Giuseppe Battaglia, Michael J. Marino, Ferdinando Nicoletti

Research output: Contribution to journalArticlepeer-review


In recent years there have been tremendous advances in our understanding of the circuitry of the basal ganglia and our ability to predict the behavioural effects of specific cellular changes in this circuit on voluntary movement. These advances, combined with a new understanding of the rich distribution and diverse physiological roles of metabotropic glutamate receptors in the basal ganglia, indicate that these receptors might have a key role in motor control and raise the exciting possibility that they might provide therapeutic targets for the treatment of Parkinson's disease and related disorders.

Original languageEnglish
Pages (from-to)787-798
Number of pages12
JournalNature Reviews Neuroscience
Issue number10
Publication statusPublished - Oct 2005

ASJC Scopus subject areas

  • Neuroscience(all)
  • Cell Biology


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