Since their discovery in the mid-1980s, metabotropic glutamate (mGlu) receptors have gained a prominent role in neuroscience for their modulatory activity on glutamatergic neurotransmission. mGlu receptors form a family of eight subtypes, divided into three groups on the basis of sequence homology, transduction mechanisms, and pharmacological profile. This article describes the molecular structure and mechanisms of activation of the three groups, focusing on the differential expression and function of each subtype and on the potential use of subtype-selective mGlu receptor ligands in the treatment of neurologic and psychiatric disorders.
- Adenylyl cyclaseAddictionAnxietyBrain tumorsDesensitizationDevelopmentEpilepsyG-protein-coupled receptorsIschemiaLong-term depressionLong-term potentiationNeurodegenerationParkinson's diseasePolyphosphoinositide hydrolysisSchizophrenia
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