Metabotropic Glutamate Receptors (mGluRs): Molecular Biology, Pharmacology and Cell Biology

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

Since their discovery in the mid-1980s, metabotropic glutamate (mGlu) receptors have gained a prominent role in neuroscience for their modulatory activity on glutamatergic neurotransmission. mGlu receptors form a family of eight subtypes, divided into three groups on the basis of sequence homology, transduction mechanisms, and pharmacological profile. This article describes the molecular structure and mechanisms of activation of the three groups, focusing on the differential expression and function of each subtype and on the potential use of subtype-selective mGlu receptor ligands in the treatment of neurologic and psychiatric disorders.

Original languageEnglish
Title of host publicationEncyclopedia of Neuroscience
PublisherElsevier Ltd
Pages801-810
Number of pages10
ISBN (Print)9780080450469
DOIs
Publication statusPublished - 2010

Keywords

  • Adenylyl cyclaseAddictionAnxietyBrain tumorsDesensitizationDevelopmentEpilepsyG-protein-coupled receptorsIschemiaLong-term depressionLong-term potentiationNeurodegenerationParkinson's diseasePolyphosphoinositide hydrolysisSchizophrenia

ASJC Scopus subject areas

  • Neuroscience(all)

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