Metabotropic receptors as targets for drugs of potential use in the treatment of neuropathic pain.

S. Chiechio, A. Copani, D. Melchiorri, A. M Teixido Canudas, M. Storto, M. Calvani, R. Nicolai, F. Nicoletti

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Abstract

Glutamate is the major neurotransmitter in the mammalian central nervous system and plays a pivotal role in both acute and chronic pain. The actions of glutamate are mediated by two receptor families: ionotropic glutamate receptors (iGluRs), and metabotropic glutamate receptors (mGluRs). Activation of glutamate receptor can elicit both hyperalgesic and analgesic effects. Eight mGluRs subtypes (mGluR1-mGluR8) have been identified and classified into three groups. Among these, group I mGluRs (mGlu1 and -5) have been implicated in the processes of central sensitization and persistent nociception, whereas activation of group II mGluRs (mGlu2/3) is effective against neuropathic or inflammatory pain. In this review we focus on the role of mGlu2/3 in the modulation of persistent pain, and on their potential use as drug targets in pain management.

Original languageEnglish
Pages (from-to)171-176
Number of pages6
JournalJournal of Endocrinological Investigation
Volume27 Suppl
Issue number6
Publication statusPublished - 2004

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ASJC Scopus subject areas

  • Endocrinology

Cite this

Chiechio, S., Copani, A., Melchiorri, D., Canudas, A. M. T., Storto, M., Calvani, M., Nicolai, R., & Nicoletti, F. (2004). Metabotropic receptors as targets for drugs of potential use in the treatment of neuropathic pain. Journal of Endocrinological Investigation, 27 Suppl(6), 171-176.